Condition

Clinical trials for Insulin Resistance

Active public studies that list Insulin Resistance as a condition.

67active studies

41recruiting now

20countries represented

9largest site network

Current studies

Status and location data reflect the registry snapshot built 2026-09-08. Verify the original record before contacting a site.

Recruiting nowPhase 1

Graded Insulin Suppression Test P&F

Insulin Resistance, HyperinsulinemiaCondition

Insulin regular, 2.0-3.2 mU/m2/min (euinsulinemia), Insulin regular, 32 mU/m2/min (hyperinsulinemia)Treatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-09-08 · NCT06592261See eligibility →

Recruiting nowPhase 1

Alpelisib Challenge Test (ACT)

Insulin Resistance, Type 2 DiabetesCondition

Alpelisib 300 mg, Alpelisib Challenge Test (ACT): Mixed Meal Tolerance Test (MMTT) after taking alpelisibTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-09-03 · NCT07778524See eligibility →

Recruiting nowPhase 1

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Insulin Resistance, Prediabetic StateCondition

Alpelisib 300 mg, PlaceboTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-08-24 · NCT06354088See eligibility →

Recruiting nowNot applicable

Prebiotic Inulin for Late-Reproductive Individuals

Obesity & Overweight, Perimenopausal WomenCondition

Inulin, Maltodextrin (Placebo)Treatment

United States1 locations

George Washington UniversitySponsor

Updated 2026-08-11 · NCT07724522See eligibility →

Recruiting nowNot applicable

A Sensory Strategy to Cut Sugary Beverages in African/American and Latine Adolescents

Obesity, Adolescent, Dietary SugarsCondition

Unsweetened Sparkling Water Replacement, Progressively Reduced Sugar Beverage ReplacementTreatment

United States3 locations

Nana Gletsu MillerSponsor

Updated 2026-08-06 · NCT07223151See eligibility →

Recruiting nowNot applicable

Small Extracellular Vesicles and Insulin Action

Obesity, Insulin ResistanceCondition

People with Metabolically Unhealthy Obesity - Low Calorie DietTreatment

United States1 locations

Washington University School of MedicineSponsor

Updated 2026-07-17 · NCT05933707See eligibility →

Recruiting nowNot applicable

DIabetes GLycemic Assessment in Newly Confirmed Episodes

Type 2 Diabetes (T2DM), Obesity Type 2 Diabetes MellitusCondition

CGM Sibionics, On-Call Extra GlucometerTreatment

Ukraine3 locations

Nazarii KobyliakSponsor

Updated 2026-07-14 · NCT07690163See eligibility →

Recruiting nowNot applicable

Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome

Obesity & Overweight, Metabolic SyndromeCondition

Kodo Millet Porridge BeverageTreatment

India1 locations

JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCHSponsor

Updated 2026-07-14 · NCT07703371See eligibility →

Recruiting nowNot applicable

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

Type 2 Diabetes, Insulin ResistanceCondition

Intervention not listedTreatment

United States1 locations

University of MichiganSponsor

Updated 2026-07-13 · NCT06007404See eligibility →

Recruiting nowPhase 1

Effect of Insulin Lowering on Lipogenesis

Hyperinsulinemia, Insulin ResistanceCondition

Placebo, Diazoxide Oral Suspension, 2 mg per kg per doseTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-07-06 · NCT07403604See eligibility →

Recruiting nowNot applicable

PREdiabetes GLycemic Impact and Data Evaluation

Pre Diabetic, Obesity & OverweightCondition

CGM Sibionics, On-Call Extra GlucometerTreatment

Ukraine3 locations

Nazarii KobyliakSponsor

Updated 2026-06-30 · NCT07599072See eligibility →

Recruiting nowNot applicable

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Obesity, Liver DiseasesCondition

ESG + lifestyle modification, Lifestyle modificationTreatment

United States2 locations

Pichamol Jirapinyo, MD, MPHSponsor

Updated 2026-06-25 · NCT06138821See eligibility →

Recruiting nowNot applicable

Exercise Effects on Adipose Tissue Structure and Function

Obesity, Metabolic SyndromeCondition

Exercise, No exerciseTreatment

United States1 locations

University of MichiganSponsor

Updated 2026-06-04 · NCT04812314See eligibility →

Recruiting nowPhase 1

Metabolic Effects of Angiotensin-(1-7)

Obesity, Insulin ResistanceCondition

Angiotensin-(1-7), SalineTreatment

United States1 locations

Vanderbilt UniversitySponsor

Updated 2026-05-22 · NCT02646475See eligibility →

Recruiting nowNot applicable

Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling

Obesity, Insulin SensitivityCondition

Diet Weight LossTreatment

United States1 locations

University of Colorado, DenverSponsor

Updated 2026-05-15 · NCT06129110See eligibility →

Recruiting nowNot applicable

Collection of Human Metabolic Tissues

Obesity, Insulin ResistanceCondition

Collection of blood samples and tissuesTreatment

France1 locations

University Hospital, MontpellierSponsor

Updated 2026-05-08 · NCT02861781See eligibility →

Recruiting nowNot applicable

Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

Insulin Resistance, Polycystic Ovary SyndromeCondition

Intervention not listedTreatment

United States1 locations

Ali ChappellSponsor

Updated 2026-05-01 · NCT05950282See eligibility →

Recruiting nowNot applicable

Metabolic Adaptations to Weight Loss With and Without Exercise

Obesity, Metabolic DiseaseCondition

MICT Exercise, No Exercise (Control)Treatment

United States1 locations

University of MichiganSponsor

Updated 2026-04-14 · NCT05806801See eligibility →

Recruiting nowNot applicable

Electro-Acupuncture for Obese Patients With Insulin Resistance

Obesity, Insulin ResistanceCondition

Acupuncture needlesTreatment

Singapore1 locations

Nanyang Technological UniversitySponsor

Updated 2026-04-09 · NCT06609200See eligibility →

Recruiting nowPhase 2

MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity

Prediabetes, Insulin ResistanceCondition

MOTS-c (MDP), PlaceboTreatment

China1 locations

Hudson BiotechSponsor

Updated 2026-04-01 · NCT07505745See eligibility →

Recruiting nowNot applicable

Effects of Cranberry on Gut and Metabolic Health

Overweight/Obesity, Metabolic SyndromeCondition

Cranberry beverage, Placebo beverageTreatment

Canada1 locations

Laval UniversitySponsor

Updated 2026-03-10 · NCT07460856See eligibility →

Recruiting nowNot applicable

Effects of Oral Glutamine Supplementation on Insulin Resistance and Functional Intestinal Disorders in Obese Patients.

Obesity, Insulin ResistanceCondition

Oral glutamine supplementation, Oral protein powder supplementationTreatment

France1 locations

University Hospital, RouenSponsor

Updated 2026-02-06 · NCT04883515See eligibility →

Recruiting nowNot applicable

New Mechanisms of Obesity

Obesity and Overweight, Insulin ResistanceCondition

Lactulose Oral ProductTreatment

United States1 locations

Yale UniversitySponsor

Updated 2026-01-28 · NCT06768827See eligibility →

Recruiting nowNot applicable

Effects of Ketone Bodies on Insulin Sensitivity

Insulin Resistance, Obesity & OverweightCondition

Growth Hormone, Human, Oral ketone supplement (KetoAid®, KE4)Treatment

Denmark1 locations

University of AarhusSponsor

Updated 2026-01-22 · NCT07359625See eligibility →

Recruiting nowPhase 3

Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)

Obesity and Cardiovascular Risk, Insulin ResistanceCondition

Metformin, PlaceboTreatment

Nigeria2 locations

University Of Nigeria Teaching HospitalSponsor

Updated 2025-12-22 · NCT07297290See eligibility →

Recruiting nowNot applicable

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

Type2 Diabetes, Type 2 Diabetes Mellitus in ObeseCondition

ObservationalTreatment

United States2 locations

Washington University School of MedicineSponsor

Updated 2025-12-18 · NCT05277558See eligibility →

Recruiting nowPhase 3

Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance

Obesity, Childhood, Insulin ResistanceCondition

Metformin 850 mg oral tablet bid, Supplemental fiber mixture (35 g total) composed of 6g of Oligofructose + 12g of resistant maltodextrin + 12g of acacia gum + 5g of PGX.Treatment

Canada1 locations

University of AlbertaSponsor

Updated 2025-11-17 · NCT04578652See eligibility →

Recruiting nowPhase 1

Mitigating the Pro-inflammatory Phenotype of Obesity

Blood Pressure, DiabetesCondition

Hydrochlorothiazide 12.5Mg Tab, Clonidine PillTreatment

United States1 locations

University of Kansas Medical CenterSponsor

Updated 2025-06-05 · NCT04934228See eligibility →

Recruiting nowNot applicable

The Acute T-Rex (Timing of Resistance Exercise) Study

Diabetes Mellitus, Type 2, Insulin ResistanceCondition

Resistance Exercise TimingTreatment

United States1 locations

University of UtahSponsor

Updated 2025-04-03 · NCT06366399See eligibility →

Recruiting nowNot applicable

Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness

Normal Weight, Overweight and ObesityCondition

Subcutaneous GLP1-RA, Subcutaneous placeboTreatment

Germany1 locations

University Hospital TuebingenSponsor

Updated 2025-03-30 · NCT06487832See eligibility →

Recruiting nowNot applicable

Efficacy and Safety of Vitamin D Supplementation in Pediatric Patients with Obesity

Vitamin D, Insulin ResistanceCondition

CholecalciferolTreatment

Mexico1 locations

Coordinación de Investigación en Salud, MexicoSponsor

Updated 2025-03-24 · NCT06847373See eligibility →

Recruiting nowNot applicable

Improving Glycemic Control With Electrical Stimulation

Obesity, OverweightCondition

Neuromuscular Electrical Stimulation (Sensory), Neuromuscular Electrical StimulationTreatment

United States1 locations

University of Texas, El PasoSponsor

Updated 2025-02-20 · NCT03947697See eligibility →

Recruiting nowNot applicable

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Non-Alcoholic Fatty Liver Disease, Obesity, MorbidCondition

Bariatric surgery, Dietitian led life style modification interventionTreatment

Hong Kong1 locations

Chinese University of Hong KongSponsor

Updated 2025-02-13 · NCT03875625See eligibility →

Recruiting nowNot applicable

Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2

Long COVID, Insulin ResistanceCondition

Adipose Tissue Biopsy, Steady State Plasma Glucose (SSPG) TestTreatment

United States2 locations

Stanford UniversitySponsor

Updated 2024-12-04 · NCT05833217See eligibility →

Recruiting nowNot applicable

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Diabetes Mellitus, Type 2, PreDiabetesCondition

Dietary Intervention Mediterranean Low Carbohydrate Diet, Dietary Intervention Standard Low Carbohydrate DietTreatment

United States1 locations

Stanford UniversitySponsor

Updated 2024-12-04 · NCT05165706See eligibility →

Recruiting nowNot applicable

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Insulin Resistance, Impaired Glucose ToleranceCondition

Low Physical Activity and Added Carbohydrate Group, Low physical Activity ControlTreatment

United States1 locations

University of New HampshireSponsor

Updated 2024-07-17 · NCT05912348See eligibility →

Recruiting nowNot applicable

Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort

Infertility, Female, Polycystic Ovary SyndromeCondition

Intervention not listedTreatment

Hungary1 locations

Semmelweis UniversitySponsor

Updated 2023-12-18 · NCT06167135See eligibility →

Recruiting nowNot applicable

Exercise Training on Brain Insulin Responsiveness

Insulin Resistance, ObesityCondition

single bout of moderate intensity continuous training (MICT), single bout of High Intensity Interval Training (HIIT)Treatment

Germany1 locations

University Hospital TuebingenSponsor

Updated 2023-11-08 · NCT06039787See eligibility →

Recruiting nowNot applicable

Leipzig Adipose Tissue Childhood Cohort

Childhood Obesity, Insulin ResistanceCondition

Intervention not listedTreatment

Germany1 locations

University of LeipzigSponsor

Updated 2023-11-07 · NCT02208141See eligibility →

Recruiting nowNot applicable

Effect of Timed-Restricted Eating on Metabolic Health

Obesity, Non-Alcoholic Fatty Liver DiseaseCondition

Early time restricted eating, Late time restricted eatingTreatment

Netherlands1 locations

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Sponsor

Updated 2023-09-29 · NCT06061042See eligibility →

Recruiting nowNot applicable

Dietary Strategies for Remission of Type 2 Diabetes

Diabetes Mellitus, Type 2, Overweight and ObesityCondition

Energy restricted diet, Low carbohydrate high fat dietTreatment

Norway1 locations

University of BergenSponsor

Updated 2022-07-08 · NCT04943926See eligibility →

Opening soonPhase 2

Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity

Insulin Resistance, ObesityCondition

Alpha-lipoic acid, MirabegronTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-09-08 · NCT05713799See eligibility →

Opening soonNot applicable

Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS

PCOS (Polycystic Ovary Syndrome), Insulin ResistanceCondition

Metformin, İnositolTreatment

Turkey (Türkiye)1 locations

Dicle UniversitySponsor

Updated 2026-08-18 · NCT07770711See eligibility →

Opening soonPhase 3

Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome

Schizophrenia Disorder, Metabolic SyndromeCondition

Semaglutide + TAU, Placebo + TAUTreatment

Locations pending0 locations

All India Institute of Medical Sciences, BhubaneswarSponsor

Updated 2026-08-18 · NCT07770282See eligibility →

Opening soonNot applicable

Evaluation of Neuregulin-4 (NRG4) Levels in Obese and Non-Obese Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM), Obesity Type 2 Diabetes MellitusCondition

Intervention not listedTreatment

Turkey (Türkiye)1 locations

GÜLDEN ANATACASponsor

Updated 2026-07-29 · NCT07734558See eligibility →

Opening soonEarly Phase 1

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Obesity (BMI>30), Insulin ResistanceCondition

human insulinTreatment

United States1 locations

University of Missouri-ColumbiaSponsor

Updated 2026-07-28 · NCT07653464See eligibility →

Opening soonNot applicable

Effects of Exercise Sequence and Meal Sequence on Weight Management Among Children and Adolescents With Overweight or Obesity: The STEP Trial

Obesity & Overweight, Insulin ResistanceCondition

Carbohydrate-last eating, Sequential trainingTreatment

China9 locations

Peking UniversitySponsor

Updated 2026-07-17 · NCT07712068See eligibility →

Opening soonNot applicable

"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"

Diabetes Mellitus, Type 2, ObesityCondition

Supervised Exercise Training Program, mHealth Unsupervised Exercise Program (ActiVital App)Treatment

Spain1 locations

Escuela Universitaria de OsunaSponsor

Updated 2026-07-06 · NCT07685080See eligibility →

Opening soonPhase 1

Human Models of Selective Insulin Resistance: Pancreatic Clamp

Insulin Resistance, HyperinsulinemiaCondition

Insulin human, Octreotide AcetateTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-02-06 · NCT06558422See eligibility →

Opening soonNot applicable

The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old

Insulin Resistance, Inflammation BiomarkersCondition

time restricted eating with caloric restriction, time restricted eating without caloric restrictionTreatment

Jordan1 locations

University of JordanSponsor

Updated 2025-04-04 · NCT06911918See eligibility →

Invitation onlyNot applicable

Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance

Insulin Resistance, Insulin SensitivityCondition

Intervention not listedTreatment

United States1 locations

Stanford UniversitySponsor

Updated 2026-05-13 · NCT04708535See eligibility →

Invitation onlyNot applicable

Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)

Cardiovascular Risk Factors, Insulin ResistanceCondition

STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health AssessmentTreatment

Czechia1 locations

Nemocnice AGEL Trinec-Podlesi a.s.Sponsor

Updated 2026-04-27 · NCT07551960See eligibility →

Invitation onlyNot applicable

Physiologic and Functional Adaptations of Insulin Sensitive Tissues

Diabetes, Insulin ResistanceCondition

Endoscopy biopsy, Surgical biopsyTreatment

United States1 locations

Vanderbilt University Medical CenterSponsor

Updated 2025-12-18 · NCT03407833See eligibility →

Active, not recruitingNot applicable

Precision Nutrition and Metabolic Function

Obesity, Insulin ResistanceCondition

Mediterranean diet, Low-carbohydrate, ketogenic dietTreatment

United States1 locations

Washington University School of MedicineSponsor

Updated 2026-07-06 · NCT04131166See eligibility →

Active, not recruitingNot applicable

Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia

Overweight and Obesity, HyperandrogenemiaCondition

Mediterranean-based, carbohydrate restricted, calorie reduced dietTreatment

United States1 locations

University of Missouri-ColumbiaSponsor

Updated 2026-03-17 · NCT06998238See eligibility →

Active, not recruitingNot applicable

MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients

Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM)Condition

Laparoscopic Sleeve Gastrectomy (LSG)Treatment

China1 locations

yu li，MDSponsor

Updated 2026-03-12 · NCT07464223See eligibility →

Active, not recruitingPhase 1

Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity

Insulin Resistance, HealthyCondition

Phentolamine, SalineTreatment

United States1 locations

Vanderbilt University Medical CenterSponsor

Updated 2026-03-02 · NCT03318094See eligibility →

Active, not recruitingNot applicable

Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health

Obesity, Insulin ResistanceCondition

Metabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic dietTreatment

United States1 locations

Washington University School of MedicineSponsor

Updated 2026-01-27 · NCT02706262See eligibility →

Active, not recruitingNot applicable

Study to Evaluate the Efficacy of an Avocado Dietary Supplement

Overweight, Metabolic HealthCondition

Metavo Supplement, PlaceboTreatment

United States1 locations

SP Nutraceuticals Inc.Sponsor

Updated 2026-01-21 · NCT07354308See eligibility →

Active, not recruitingNot applicable

Probiotics and Insulin Resistance in Obese Asthmatics

Asthma, ObesityCondition

Probiotic, PlaceboTreatment

United States1 locations

University of Alabama at BirminghamSponsor

Updated 2026-01-16 · NCT05949255See eligibility →

This page shows the first 60 studies. Use the full search to filter all matches.

Related conditions

Obesity1,102 Obesity & Overweight220 Overweight205 Overweight and Obesity130 Type 2 Diabetes108 Hypertension107

How current is this page?

The page is rebuilt from the public registry feed. Each trial card shows the registry update date. Recruitment can still change between builds.

Does appearing here mean I qualify?

No. These pages are discovery indexes. Only a study team can confirm eligibility after reviewing the complete protocol criteria.