Clinical trial

Leipzig Adipose Tissue Childhood Cohort

Recruiting now · Not applicable · 1 countries · Registry ID NCT02208141

Recruiting nowNot applicableObservational

What this study is about

In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to Not listed

SexAll

Healthy volunteersAccepted

ConditionChildhood Obesity, Insulin Resistance

Full registry criteria

Inclusion Criteria: * body weight: 3000 g - 180 kg * suitable surgical procedure * signed informed consent by the guardians and the study participant, if older 12 years Exclusion Criteria: * severe chronic and inflammatory diseases * acute or chronic infections * oncological diseases * clotting disorders * complications during surgical procedure * drug treatment * nil by mouth

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Adipose tissue dysfunction10 years

Adipose tissue dysfunction is assessed by evaluation of adipocyte size and number (hypertrophy vs. hyperplasia), adipocyte proliferation and differentiation, (lipid) cellular metabolism, inflammation, gene expression, fibrosis, and others; the association of AT dysfunction with clincial phenotype will be assessed

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Center for Pediatric Research Leipzig (CPL)🇩🇪 Leipzig, Saxony, Germany

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Antje Körner, Prof. Dr.Contact

Email · Call 0049/(0)341-9726854