Clinical trial

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Recruiting now · Not applicable · 1 countries · Registry ID NCT05912348

Recruiting nowNot applicableInterventional

What this study is about

This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 30 Years

SexAll

Healthy volunteersAccepted

ConditionInsulin Resistance, Impaired Glucose Tolerance, Obesity, Metabolic Disturbance

Full registry criteria

Inclusion Criteria: * 18-30 years of age * Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (\>2 days/week). * Fair cardiorespiratory fitness levels (Men: VO2\>38.4 ml/kg/min; Women: VO2\>32.6 ml/kg/min). Exclusion Criteria: * Hypertension (resting or diagnosed) * Impaired fasting blood glucose (\>100mg/dL) * Diagnosed cardiovascular disease * Diagnosed diabetes * Diagnosed cancer * Diagnosed chronic kidney disease * Diagnosed musculoskeletal disorders that prevents the individual from exercising on a bike.

Treatments and study arms

Low Physical Activity and Added Carbohydrate Group

Behavioral

Young men and women will transition into a low physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group. One of the control groups will undergo a low physical activity intervention.

Low physical Activity Control

Behavioral

Young men and women will transition into a low physically active lifestyle for 10 days.

High Physical Activity and Added Carbohydrate Group

Behavioral

Young men and women will transition into a high physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group.

Primary outcomes

To determine if low physical activity alone contributes to insulin resistance in healthy, recreationally active young men and women compared to men and women that reduce their physical activity and consume added sugar-sweetened beverages.10 days

We will use HOMA-IR to measure changes in insulin resistance across the 4 study groups

To determine if the combined low physical activity and added carbohydrates impairs 24-hour glucose regulation compared the other study interventions.10 days

Compare 24-hour glucose regulation (mmol/L) measurements across the four study groups

To determine if fat oxidation is impaired when participants reduce their physical activity levels and consume added carbohydrates compared to the three interventions10 days

Compare the change in fat oxidation after the 10 day intervention

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of New Hampshire Cardiometabolic Research Laboratory🇺🇸 Durham, New Hampshire, United States

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Michael Brian, PhDContact

Email · Call 603-862-1693

Michael Brian, PhDPrincipal Investigator