Clinical trial

Exercise Training on Brain Insulin Responsiveness

Recruiting now · Not applicable · 1 countries · Registry ID NCT06039787

Recruiting nowNot applicableInterventional

What this study is about

The overarching goal of the current study is to investigate the effect of one acute bout of exercise on the brain insulin responsiveness in a cross-over study design. To this end, investigators will compare the effect of two single endurance exercise sessions with different intensities, namely moderate intensity continuous training (MICT) and high-intensity-interval-training (HIIT), which will be performed in a randomized order. This will be compared to a waiting control condition.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age20 Years to 65 Years

SexAll

Healthy volunteersAccepted

ConditionInsulin Resistance, Obesity

Full registry criteria

Inclusion Criteria: * BMI between ≥ 19.5 to 39 kg/m2- * Less than 150 min/week for moderate-intensity physical activity * Less than 75 min/week for Vigorous- intensity exercise (WHO recommendations for regular physical activity of adults) * Written consent to participate in the study * Written consent to be informed about incidental findings Exclusion Criteria * Type 2 diabetes, cardiovascular diseases such as chronic heart failure, myocardial infarction, status post stroke * Limitations to participate in ergometer-based exercise (balance and coordination disorders, orthopedic problems, …) * Insufficient knowledge of the German language * Persons who cannot legally give consent * Pregnancy or lactation * History of severe mental or somatic disorders including neurological diseases (incl. epileptic seizures and migraines) * Taking psychotropic drugs * Taking medications that influence glucose metabolism * Regular use of analgesic drugs * Taking anticoagulant agents * Previous bariatric surgery * Acute infection within the last 4 weeks * Hemoglobin values less than 12g/dl for women, less than 14 g/dl for men * Other diseases that in the opinion of the investigator may jeopardize the success of the study or indicate a risk to the volunteer * Current participation in a lifestyle intervention study or a pharmaceutical study * Metal implants which cannot be removed as pacemakers, artificial heart valve, electrical devices as insulin pumps, large tattoos, retainer over more than 4 teeth, contraceptive coil, implanted magnetic metal parts as screws or plates after a surgery * Persons with claustrophobia * Temperature-sensitive person * Persons with tinnitus or increased sensitivity to loud sounds

Treatments and study arms

single bout of moderate intensity continuous training (MICT)

Behavioral

the MICT consists of 60 min continuous cycling

single bout of High Intensity Interval Training (HIIT)

Behavioral

HIIT consists of 10-min warm-up at the power output corresponding to 50% peak power output (PPO), 4 x 4-min intervals at a power output corresponding to 75% PPO with a 4-min active resting period at 30% PPO to recover

waiting control

Behavioral

sitting in a waiting room for 60 min

Primary outcomes

Cerebral response after intranasal insulin administration1 hour after exercise or waiting control

The resting-state cerebral response from before to after intranasal insulin administration after a single bout of HIIT or MICT exercise compared to a control condition without exercise (i.e., waiting control)

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University Clinic Tübingen, Department of Internal Medicine IV🇩🇪 Tübingen, Germany

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Stephanie Kullmann, PhDContact

Email · Call +49 7071 29