Clinical trial

Effects of Cranberry on Gut and Metabolic Health

Recruiting now · Not applicable · 1 countries · Registry ID NCT07460856

Recruiting nowNot applicableInterventional

What this study is about

The consumption of plant-based foods, particularly berries, has been associated with improved health due to their high content of bioactive compounds. Among these, polyphenols-especially proanthocyanidins (PACs)-may offer protective effects against chronic diseases related to overweight and obesity. Cranberries are naturally rich in PACs and may positively influence metabolic health by modulating the gut microbiota. However, their specific effects on intestinal integrity and broader metabolic outcomes remain underexplored. The primary aim of this study is to assess the effects of cranberry supplementation on glucose metabolism, insulin sensitivity, blood lipid levels, and the composition and function of the gut microbiota in overweight and obese individuals. This randomized, double-blind, placebo-controlled, crossover clinical trial will include two 12-week intervention periods-one with a cranberry beverage and one with a placebo-separated by a 4-week washout period and preceded by a 2-week lifestyle stabilization phase. Participants will undergo comprehensive metabolic assessments (glucose control, insulin sensitivity, lipid profile), body composition analysis, gut microbiota profiling, and liver fat imaging (MRI in a subsample of female participants). Additional evaluations will include markers of inflammation, appetite regulation, intestinal health, and lifestyle factors.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age25 Years to 70 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight/Obesity, Metabolic Syndrome, Insulin Resistance, Microbiota

Full registry criteria

Inclusion Criteria: * body mass index between 25 and 40 kg/m2 * at least one of the following criteria: fasting plasma insulin \>60 pmol/L, fasting glycemia between 5.5 and 6.9 mmol/L, glycated hemoglobin (HbA1c) level of 5.7- 6.4% and/or fasting triglyceride \>1.35 mmol/L. Exclusion Criteria: * to have aversion to cranberry products * regularly drinking alcohol (\>2 glasses/day) * having a significant change in body weight in the past 3 months (±5% of their body weight) due to bariatric surgery or other conditions * taking medication which may affect the study outcomes (i.e. antidiabetic and/or cholesterol or lipid-lowering medications and/or glucocorticosteroid in supraphysiological doses and/or anti-obesity medications) * taking regular probiotics and prebiotics (including fruit/berry polyphenol supplements) in the past 3 months * having eating disorders * had undergone major surgery 3 months prior to the study or if they had one planned * if they had intestinal malabsorption, cirrhosis or chronic kidney disease * being pregnant, planning a pregnancy, or breastfeeding.

Treatments and study arms

Cranberry beverage

Dietary Supplement

Daily consumption of 240 ml of cranberry beverage for 12 weeks.

Placebo beverage

Dietary Supplement

Daily consumption of 240 ml of placebo beverage for 12 weeks.

Primary outcomes

Change in glucose homeostasisPre and post each treatment (12 week/each)

Assessment of glucose concentrations during a 3-hour oral glucose tolerance test (OGTT)

Change in insulin secretionPre and post each treatment (12 week/each)

Assessment of insulin a concentrations during a 3-hour oral glucose tolerance test (OGTT)

Change in insulin secretionPre and post each treatment (12 week/each)

Assessment of C-Peptide concentrations during a 3-hour oral glucose tolerance test (OGTT)

Change in lipid profilePre and post each treatment (12 week/each)

Assessment of triglycerides, LDL-cholesterol and HDL-cholesterol

Study locations

1 locations were listed when this page was built. The first 40 are shown.

INAF, Université Laval🇨🇦 Québec, Quebec, Canada

Open map

Julie Marois, M.Sc.Contact

Email · Call 1-418-656-5258