Clinical trial

Exercise Effects on Adipose Tissue Structure and Function

Recruiting now · Not applicable · 1 countries · Registry ID NCT04812314

Recruiting nowNot applicableInterventional

What this study is about

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 40 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain

Full registry criteria

Inclusion Criteria: * Age: 18-40 * Body Mass Index: 27-45 kg/m2 * No regularly planned exercise/physical activity for at least 6 months * Women must have regularly occurring menses and must be premenopausal Exclusion Criteria: * Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism, or inflammation * Weight instability ≥ ± 6 pounds in the last 3 months * Tobacco or e-cigarette users * Women must not be pregnant or actively lactating

Treatments and study arms

Exercise

Behavioral

Participants will complete a moderate intensity continuous exercise 4 days/week.

No exercise

Behavioral

Participants will remain sedentary throughout the duration of the study.

Primary outcomes

Oral Glucose Tolerance Test (OGTT)2 hours

A test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood will be completed at each clinical visit appointment..

Adipose Tissue Fibrosis30 minutes

measured histologically using Sirus Red Staining, quantified using ImageJ software at each clinical visit appointment.

Muscle Capillarization30 minutes

measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.

Adipose Capillarization30 minutes

measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.

Fat Cell Size3 minutes

measured histologically using Hematoxylin and eosin (H \& E) staining, quantified using ImageJ software at each clinical visit appointment.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Michigan🇺🇸 Ann Arbor, Michigan, United States

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Jeffrey F HorowitzContact

Email · Call 7346471076