Clinical trial

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Recruiting now · Not applicable · 1 countries · Registry ID NCT03875625

Recruiting nowNot applicableInterventional

What this study is about

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years

SexAll

Healthy volunteersNot accepted

ConditionNon-Alcoholic Fatty Liver Disease, Obesity, Morbid, Brown Fat, Metabolic Disease, Diabetes Mellitus, Insulin Resistance, Abdominal Subcutaneous Fat

Full registry criteria

Inclusion Criteria: * BMI ≥ 25-30 kg/m2 * BMI ≥ 30 kg/m2 with Metabolic syndrome * BMI ≥ 35 kg/m2 for morbid obesity Exclusion Criteria: * Other kind of hepatic diseases * Under medications known to affect liver fat * Waist circumference ≥ 150 cm * Weight ≥ 250 kg * MRI contraindications

Treatments and study arms

Bariatric surgery

Procedure

Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)

Dietitian led life style modification intervention

Behavioral

Intensive 6 months life style changes supervised by diatitians.

Conventional care (control)

Behavioral

receive routine care

Primary outcomes

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgeryone year

Abdominal subcutaneous fat in milliliters

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery 2one year

Abdominal Visceral fat in milliliters

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery- 3one year

Liver fat in percentage (%).

Use of modified Dixon Magnetic Resonance Imaging method to measure the response of adipose tissue in different organs following life style modification program or Bariatric surgery- 4one year

pancreatic fat in percentage (%).

Use of modified Dixon Magnetic Resonance Imaging method to assess the relationship between Brown Adipose Tissue and Non Alcoholic Fatty Liver Diseaseone year

Brown fat in milliliters

Blood biochemistry for assessing β-cell function and insulin resistance (IR)one year

Homeostatic model assessment (HOMA) (Fasting glucose in nanomoles per liter (nmol/L) and insulin in (micro-units Per Litre).

Blood biochemistry- 1one year

To measure Triglycerides in millimoles per litre (mmol/L)

Blood biochemistry- 2one year

To measure high density lipoproteins in millimoles per litre (mmol/L)

Study locations

1 locations were listed when this page was built. The first 40 are shown.

The Chinese University of Hong Kong, Prince of Wale Hospital🇭🇰 Hong Kong, Shatin, Hong Kong

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Winnie C Chu, MDContact

Email · Call (852) 3505 1007

Winnie C Chu, MDPrincipal Investigator