Country

Clinical trials in United Kingdom

Active obesity and GLP-1 studies with at least one location in United Kingdom.

87active studies

49recruiting now

35countries represented

76largest site network

Current studies

Status and location data reflect the registry snapshot built 2026-09-08. Verify the original record before contacting a site.

Recruiting nowPhase 2

A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight

Obesity, OverweightCondition

BI 3034701, Placebo matching BI 3034701Treatment

Australia, Canada54 locations

Boehringer IngelheimSponsor

Updated 2026-09-03 · NCT07662122See eligibility →

Recruiting nowPhase 3

Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

ObesityCondition

Ribupatide, SemaglutideTreatment

Australia, Bulgaria59 locations

KaileraSponsor

Updated 2026-09-01 · NCT07284979See eligibility →

Recruiting nowPhase 3

A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities

Obesity, OverweightCondition

Orforglipron, PlaceboTreatment

Israel, Italy34 locations

Eli Lilly and CompanySponsor

Updated 2026-08-24 · NCT06672939See eligibility →

Recruiting nowPhase 2

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Type 2 DiabetesCondition

LY3457263, PlaceboTreatment

Canada, Germany60 locations

Eli Lilly and CompanySponsor

Updated 2026-08-21 · NCT06897475See eligibility →

Recruiting nowNot applicable

Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial

ObesityCondition

Intensive weight loss intervention, Bariatric surgeryTreatment

Denmark, United Kingdom14 locations

Carsten DirksenSponsor

Updated 2026-08-21 · NCT06309238See eligibility →

Recruiting nowNot applicable

Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease

Healthy, Fatty LiverCondition

Bioimpedence Vector AnalysisTreatment

United Kingdom1 locations

Richmond Research InstituteSponsor

Updated 2026-08-19 · NCT04873258See eligibility →

Recruiting nowNot applicable

Effects of Obesity on Autophagy and mTORC1 Signalling in Skeletal Muscle

Overweight and Obese AdultsCondition

Skeletal muscle biopsy, venous blood samplingTreatment

United Kingdom1 locations

University of BirminghamSponsor

Updated 2026-08-19 · NCT07774676See eligibility →

Recruiting nowNot applicable

Safety and Effectiveness of Orbera365™ Intragastric Balloon System

ObesityCondition

Intragastric BalloonTreatment

Czechia, Spain4 locations

Boston Scientific CorporationSponsor

Updated 2026-08-13 · NCT07062094See eligibility →

Recruiting nowPhase 1

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.

Healthy Participants, ObesityCondition

AZD1043, PlaceboTreatment

United Kingdom, United States3 locations

AstraZenecaSponsor

Updated 2026-08-10 · NCT07511205See eligibility →

Recruiting nowPhase 4

Fibrosis Lessens After Metabolic Surgery

Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver DiseaseCondition

Metabolic surgery, Incretin-Based TherapyTreatment

Brazil, Canada22 locations

The Cleveland ClinicSponsor

Updated 2026-07-31 · NCT06374875See eligibility →

Recruiting nowPhase 1

A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body

Healthy, ObesityCondition

Formulation A, Formulation B6Treatment

United Kingdom1 locations

Boehringer IngelheimSponsor

Updated 2026-07-30 · NCT07407348See eligibility →

Recruiting nowNot applicable

Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity

Childhood ObesityCondition

Intervention not listedTreatment

United Kingdom1 locations

Alder Hey Children's NHS Foundation TrustSponsor

Updated 2026-07-14 · NCT07702825See eligibility →

Recruiting nowPhase 3

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

ObesityCondition

NNC0487-0111, Placebo (matched to NNC0487-0111)Treatment

Argentina, Australia72 locations

Novo Nordisk A/SSponsor

Updated 2026-07-09 · NCT07339423See eligibility →

Recruiting nowNot applicable

Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study

Pediatric Obesity, Type 2 DiabetesCondition

Low-energy diet, Qualitive interview - LED participantsTreatment

United Kingdom1 locations

Nottingham University Hospitals NHS TrustSponsor

Updated 2026-07-09 · NCT06572345See eligibility →

Recruiting nowPhase 4

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

ObesityCondition

Tirzepatide, Standard of CareTreatment

United Kingdom30 locations

Eli Lilly and CompanySponsor

Updated 2026-07-07 · NCT07247084See eligibility →

Recruiting nowNot applicable

Periodontal Assessment of a Bariatric Care Population

Bariatric Surgery Candidate, ObesityCondition

Intervention not listedTreatment

United Kingdom4 locations

Queen Mary University of LondonSponsor

Updated 2026-07-02 · NCT04851470See eligibility →

Recruiting nowNot applicable

Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)

Type 2 DiabetesCondition

Total Diet Replacement (TDR) ProgramTreatment

United Kingdom1 locations

University of EdinburghSponsor

Updated 2026-06-18 · NCT07364045See eligibility →

Recruiting nowPhase 1, Phase 2

A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity

Overweight and ObesityCondition

WVE-007Treatment

Moldova, Romania6 locations

Wave Life Sciences USA, Inc.Sponsor

Updated 2026-06-02 · NCT06842186See eligibility →

Recruiting nowNot applicable

The Effect of Time-Restricted Eating in Cardiometabolic Health

Obesity, PreDiabetesCondition

Time restricted eating, Extended eating windowTreatment

United Kingdom1 locations

Cambridge University Hospitals NHS Foundation TrustSponsor

Updated 2026-05-28 · NCT05866406See eligibility →

Recruiting nowNot applicable

Acute Impact of Whey Protein-enriched Milk Fat Globule Membrane Supplementation on Postprandial Markers of Heart and Brain Health

Cardiovascular Diseases, CognitionCondition

Whey protein-enriched milk fat globule membrane supplement, Whey protein-based supplementTreatment

United Kingdom1 locations

Loughborough UniversitySponsor

Updated 2026-05-20 · NCT06953232See eligibility →

Recruiting nowNot applicable

Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis

Psoriatic Arthritis (PsA), Obesity & OverweightCondition

Ixekizumab, TirzepatideTreatment

United Kingdom4 locations

NHS Greater Glasgow and ClydeSponsor

Updated 2026-05-04 · NCT07443956See eligibility →

Recruiting nowNot applicable

Rebalancing the Fat Content of the Heart and Muscles

Diabetes Mellitus Type 2Condition

Semaglutide administration plus dietary counselling and physical activity encouragement, Semaglutide plus a personalised and supervised program of resistance and endurance trainingTreatment

United Kingdom1 locations

University of AberdeenSponsor

Updated 2026-04-30 · NCT07065383See eligibility →

Recruiting nowPhase 1

A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese

Overweight, ObeseCondition

Glucose-dependent Insulinotropic Polypeptide (GIP), CagrilintideTreatment

United Kingdom1 locations

Novo Nordisk A/SSponsor

Updated 2026-04-13 · NCT07411560See eligibility →

Recruiting nowNot applicable

Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation

Impaired Glucose Regulation, Impaired Glucose Tolerance (Prediabetes)Condition

Lab4p Probiotic Consortium, PlaceboTreatment

United Kingdom1 locations

Leeds Beckett UniversitySponsor

Updated 2026-03-31 · NCT07073781See eligibility →

Recruiting nowNot applicable

Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment

Muscle Mass and Strength, Obesity & OverweightCondition

Progressive Resistance Exercise Training Program, Habitual physical activity guidelinesTreatment

United Kingdom1 locations

University of ExeterSponsor

Updated 2026-03-27 · NCT07457437See eligibility →

Recruiting nowPhase 3

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic FormCondition

Setmelanotide, PlaceboTreatment

United Kingdom, United States11 locations

Rhythm Pharmaceuticals, Inc.Sponsor

Updated 2026-02-12 · NCT06760546See eligibility →

Recruiting nowNot applicable

A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults

Hypertension, Obesity & OverweightCondition

Tirzepatide, Anti-Hypertensive medicationsTreatment

United Kingdom1 locations

Cambridge University Hospitals NHS Foundation TrustSponsor

Updated 2026-01-29 · NCT07364175See eligibility →

Recruiting nowNot applicable

Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice

Monogenic ObesityCondition

Semaglutide (administered by PDS290 pen-injector)Treatment

France, Germany7 locations

Prof. Dr. Martin WabitschSponsor

Updated 2026-01-08 · NCT07302802See eligibility →

Recruiting nowNot applicable

Impact of Beta-glucan Supplementation During Calorie and Carbohydrate-restricted Diet on Body Weight and Body Fat Loss, Appetite, and Gastrointestinal Appetite Hormones.

Overweight and Obese WomenCondition

Beta-glucan addition to a restricted calorie of meal replacements and carbohydrate diet., Cellulose (Placebo) addition to a restricted calorie of meal replacements and carbohydrate diet.Treatment

United Kingdom1 locations

University of GlasgowSponsor

Updated 2025-12-23 · NCT07299942See eligibility →

Recruiting nowNot applicable

Comorbid Obesity and Depression With an Anti-inflammatory Medication

Obesity, Major Depressive DisorderCondition

Minocycline 200mgTreatment

United Kingdom1 locations

King's College LondonSponsor

Updated 2025-11-14 · NCT06537921See eligibility →

Recruiting nowNot applicable

Effects of a Collagen Supplement on Quality of Life, Appetite and Glycaemic Control

Quality of Life, AppetiteCondition

Collagen peptide supplement, PlaceboTreatment

United Kingdom1 locations

King's College LondonSponsor

Updated 2025-11-14 · NCT07229014See eligibility →

Recruiting nowNot applicable

Global Overweight and oBesE (GLOBE) Patient Registry, Development and Implementation of Disease-specific: Severity, Quality of Life and Cost Instruments.

Overweight (BMI > 25), Obesity & OverweightCondition

Intervention not listedTreatment

United Kingdom1 locations

Medialis Ltd.Sponsor

Updated 2025-11-14 · NCT07229027See eligibility →

Recruiting nowNot applicable

Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction

Overweight and Obese Adults, HealthyCondition

Phase 1 - Maintenance Diet, Phase 2 - Weight loss dietTreatment

United Kingdom1 locations

University of AberdeenSponsor

Updated 2025-07-18 · NCT07065643See eligibility →

Recruiting nowNot applicable

The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease

Bronchial Asthma, BronchiectasisCondition

Intervention not listedTreatment

United Kingdom1 locations

University College, LondonSponsor

Updated 2025-07-11 · NCT07060079See eligibility →

Recruiting nowNot applicable

The Effect of Exercise in Patients Awaiting Bariatric Surgery

Bariatric Surgery Candidate, ObesityCondition

Online exercise interventionTreatment

United Kingdom1 locations

University College, LondonSponsor

Updated 2025-05-21 · NCT05235945See eligibility →

Recruiting nowNot applicable

The Poor Responders Study

Bariatric Surgery Candidate, Obesity, MorbidCondition

Gut hormonesTreatment

United Kingdom1 locations

Imperial College LondonSponsor

Updated 2025-05-09 · NCT05404061See eligibility →

Recruiting nowNot applicable

Personalized Responses to Dietary Composition Trial 3

Diabetes, Heart DiseasesCondition

Dietary InterventionTreatment

United Kingdom, United States2 locations

Zoe Global LimitedSponsor

Updated 2025-04-16 · NCT04735835See eligibility →

Recruiting nowNot applicable

EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality

Atrial Fibrillation, Coronary Heart DiseaseCondition

Intervention not listedTreatment

United Kingdom1 locations

Future Genetics LimitedSponsor

Updated 2025-03-10 · NCT03987633See eligibility →

Recruiting nowNot applicable

The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.

Heart Failure, Heart Failure With Reduced Ejection FractionCondition

Diet interventionTreatment

Jersey, United Kingdom2 locations

University of OxfordSponsor

Updated 2025-02-25 · NCT05942287See eligibility →

Recruiting nowNot applicable

The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.

Healthy, Older AdultsCondition

Nitrate-rich beetroot juice plus calorie-restricted diet, Nitrate-rich beetroot juice plus weight-maintenance dietTreatment

United Kingdom1 locations

Moira TaylorSponsor

Updated 2024-12-24 · NCT06151015See eligibility →

Recruiting nowNot applicable

The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes

Steroid-Induced Diabetes, Steroid Induced HyperglycemiaCondition

Semaglutide Oral Product, Metformin Oral TabletTreatment

United Kingdom1 locations

Imperial College LondonSponsor

Updated 2024-10-02 · NCT06318442See eligibility →

Recruiting nowNot applicable

The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, ObesityCondition

Diet interventionTreatment

United Kingdom1 locations

University of OxfordSponsor

Updated 2024-04-24 · NCT05878912See eligibility →

Recruiting nowNot applicable

A UK Registry for Metabolic and Bariatric Endoscopic Interventions

Obesity, Diabetes Mellitus, Type 2Condition

Endoscopic gastric suturing, Endoscopic gastric plicationTreatment

United Kingdom1 locations

Cleveland Clinic LondonSponsor

Updated 2024-03-15 · NCT06305208See eligibility →

Recruiting nowNot applicable

Biomarkers in Patients With Suspected HFpEF

Heart Failure, ObesityCondition

Plasma biomarker levelsTreatment

United Kingdom3 locations

NHS Greater Glasgow and ClydeSponsor

Updated 2024-02-13 · NCT06101693See eligibility →

Recruiting nowNot applicable

Who Will Benefit From Bariatric Surgery for Diabetes?

Diabetes Mellitus, Type 2, ObesityCondition

Roux-en-Y gastric bypass (RYGB)Treatment

United Kingdom1 locations

Imperial College LondonSponsor

Updated 2023-04-19 · NCT03842475See eligibility →

Recruiting nowNot applicable

Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes

Obesity, Pregnancy in DiabeticCondition

ObservationalTreatment

United Kingdom1 locations

Chelsea and Westminster NHS Foundation TrustSponsor

Updated 2023-03-03 · NCT05753124See eligibility →

Recruiting nowNot applicable

The European NAFLD Registry

NAFLD, NASHCondition

Intervention not listedTreatment

Belgium, Finland37 locations

Newcastle UniversitySponsor

Updated 2023-01-06 · NCT04442334See eligibility →

Recruiting nowNot applicable

Gut Hormones and Roux en Y Gastric Bypass

Obesity, Type 2 DiabetesCondition

Roux en Y Gastric Bypass Surgery, Gut hormone infusionTreatment

United Kingdom1 locations

Imperial College LondonSponsor

Updated 2021-04-20 · NCT01945840See eligibility →

Recruiting nowNot applicable

Nottingham Community Liver Biomarkers Cohort

Chronic Liver Disease, Alcohol Use DisorderCondition

Fibrosis BiomarkersTreatment

United Kingdom1 locations

University of NottinghamSponsor

Updated 2019-02-08 · NCT02037867See eligibility →

Opening soonNot applicable

A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1 Agonists

Obesity & Overweight, GLP - 1Condition

Ubiquinol 100 MG Oral Capsule, PlaceboTreatment

United Kingdom1 locations

StudySetGoSponsor

Updated 2026-09-01 · NCT07789106See eligibility →

Opening soonNot applicable

Weight and Metabolic Management Study

Overweight, ObesityCondition

elénzia CONTROL®, PlaceboTreatment

United Kingdom1 locations

ElenziaSponsor

Updated 2026-08-28 · NCT07789223See eligibility →

Opening soonNot applicable

3D Reconstruction, VR and Machine Learning in Body Image in Bariatrics

Obesity (Disorder), Body ImageCondition

Body Image Counselling with Virtual RealityTreatment

United Kingdom1 locations

Imperial College LondonSponsor

Updated 2026-06-25 · NCT07668492See eligibility →

Opening soonNot applicable

Glycaemic Response of Arabic Bread

Overweight, ObesityCondition

Control Bread, Chickpea-Enriched Arabic BreadTreatment

United Kingdom1 locations

University of NottinghamSponsor

Updated 2026-06-22 · NCT07652320See eligibility →

Opening soonNot applicable

Effects of HIIT Following PTR Programme

Obesity & Overweight, Type 2 DiabetesCondition

ExerciseTreatment

United Kingdom1 locations

University of NottinghamSponsor

Updated 2026-05-04 · NCT07565935See eligibility →

Opening soonNot applicable

Effect of Early Time-Restricted Eating on Appetite, Appetite-Regulatory Hormones and Energy Intake

Healthy Adult MaleCondition

Normal diet, early Time-Restricted Eating (eTRE)Treatment

United Kingdom1 locations

University of GlasgowSponsor

Updated 2026-04-16 · NCT07500792See eligibility →

Opening soonPhase 4

DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies

Cardiovascular DiseasesCondition

semaglutide, TirzepatideTreatment

United Kingdom1 locations

Cambridge University Hospitals NHS Foundation TrustSponsor

Updated 2026-03-19 · NCT07483801See eligibility →

Opening soonNot applicable

Group Skills Training for Body Awareness and Managing Emotions

Body Awareness, ObesityCondition

Polyvagal informed skills training groupTreatment

United Kingdom1 locations

Royal Holloway UniversitySponsor

Updated 2026-01-07 · NCT07315763See eligibility →

Opening soonNot applicable

The Oswestry Metabolic BONE Cohort

OsteoporosisCondition

MRI, Computed tomographyTreatment

United Kingdom1 locations

Robert Jones and Agnes Hunt Orthopaedic and District NHS TrustSponsor

Updated 2025-06-10 · NCT07014306See eligibility →

Opening soonNot applicable

Obesity Prevention in Children and Young People Treated for Acute Lymphoblastic Leukaemia with ALLTogether

Diet Intervention, Physical Activity InterventionCondition

Diet, Diet and physical activityTreatment

Spain, United Kingdom2 locations

University of ExeterSponsor

Updated 2025-02-26 · NCT06846294See eligibility →

Invitation onlyNot applicable

Free Fatty Acid Effects In Type 2 Diabetes

Type 2 Diabetes, Cardiovascular DiseaseCondition

Omega-3 Fatty Acids, Semaglutide 0.25 mgTreatment

United Kingdom1 locations

University of UlsterSponsor

Updated 2026-09-01 · NCT07677995See eligibility →

This page shows the first 60 studies. Use the full search to filter all matches.

Related countries

United States1,107 China326 Canada158 France110 Spain98 Germany95

How current is this page?

The page is rebuilt from the public registry feed. Each trial card shows the registry update date. Recruitment can still change between builds.

Does appearing here mean I qualify?

No. These pages are discovery indexes. Only a study team can confirm eligibility after reviewing the complete protocol criteria.