Clinical trial

The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease

Recruiting now · Not applicable · 1 countries · Registry ID NCT07060079

Recruiting nowNot applicableObservational

What this study is about

Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis. The investigation specifically focuses on sleep-disordered breathing (SDB) in individuals with chronic respiratory disease. SDB encompasses a range of conditions, the most common of which is obstructive sleep apnoea. In obstructive sleep apnoea, periodic pauses in breathing (apnoea) lead to reduced blood oxygen levels. To detect these events, patients typically undergo sleep studies that involve monitoring oxygen saturation, heart rate, and respiratory patterns during sleep. When chronic respiratory disease and SDB coexist, breathing disturbances during sleep may be exacerbated. To identify SDB, sleep studies are commonly used to assess oxygen levels, heart rate, and breathing patterns. The objective of this research is to identify differences between patients with chronic respiratory diseases who have SDB and those who do not. This will be achieved by analysing sleep study data using a novel analytical approach. The aim is to determine whether this method can yield more detailed insights into the underlying pathophysiology of these conditions.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionBronchial Asthma, Bronchiectasis, ILD, COPD, OSAHS, OSA, Obesity Hypoventilation Syndrome (OHS)

Full registry criteria

Inclusion Criteria: * All adult patients (≥ 18years) with chronic respiratory disease with/without SDB. * patients who have had previously negative studies as a control group. * Subject is able to read, understand, and sign the informed consent form. * Willing to sleep with portable monitoring devices. Exclusion Criteria: * Patients who are under 18 years of age at the time of the index study. * Contraindications to the use of portable monitoring. * Inability to give informed consent to take part in the study.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Changes in respiratory signals entropy, oxygen saturation , and heart rate recorded using cardiorespiratory polygraphy during a 1-hour daytime and overnight sleep in healthy subjects and patients with chronic respiratory diseases with /without SDB.2 months

High entropy value greater irregularity or complexity in the respiratory signal while low entropy value more regular, predictable, or uniform respiratory patterns.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Royal Free hospital🇬🇧 London, United Kingdom

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Nawal Alotaibi, Phd studentContact

Email · Call 02080168375