Country

Clinical trials in United States

Active obesity and GLP-1 studies with at least one location in United States.

1,107active studies

621recruiting now

46countries represented

1,498largest site network

Current studies

Status and location data reflect the registry snapshot built 2026-09-08. Verify the original record before contacting a site.

Recruiting nowPhase 2

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Obesity, OverweightCondition

LY3305677, LY3841136Treatment

Argentina, United States56 locations

Eli Lilly and CompanySponsor

Updated 2026-09-08 · NCT06143956See eligibility →

Recruiting nowPhase 4

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Psoriatic Arthritis, Overweight or ObesityCondition

TirzepatideTreatment

Puerto Rico, United States55 locations

Eli Lilly and CompanySponsor

Updated 2026-09-08 · NCT06864026See eligibility →

Recruiting nowPhase 2

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Obesity, OverweightCondition

Macupatide, EloralintideTreatment

Argentina, Australia42 locations

Eli Lilly and CompanySponsor

Updated 2026-09-08 · NCT07215559See eligibility →

Recruiting nowNot applicable

Inflammation, Diabetes, Ethnicity and Obesity Cohort

Obesity, Diabetes MellitusCondition

Intervention not listedTreatment

United States1 locations

University of California, San FranciscoSponsor

Updated 2026-09-08 · NCT03022682See eligibility →

Recruiting nowNot applicable

tDCS With Cognitive Training to Reduce Impulsivity and Weight in Veterans With Obesity

ObesityCondition

Sham Transcranial Direct Current Stimulation (tDCS), Active Transcranial Direct Current Stimulation (tDCS)Treatment

United States1 locations

VA Office of Research and DevelopmentSponsor

Updated 2026-09-08 · NCT05225233See eligibility →

Recruiting nowPhase 1

Graded Insulin Suppression Test P&F

Insulin Resistance, HyperinsulinemiaCondition

Insulin regular, 2.0-3.2 mU/m2/min (euinsulinemia), Insulin regular, 32 mU/m2/min (hyperinsulinemia)Treatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-09-08 · NCT06592261See eligibility →

Recruiting nowNot applicable

Effects of Dietary Supplements on Muscle Mass and Function While Using GLP-1 Medication

Obesity & Overweight, Muscle Mass and StrengthCondition

Whey Protein Supplementation, Maltodextrin Placebo CapsulesTreatment

United States1 locations

University of California, Los AngelesSponsor

Updated 2026-09-08 · NCT07806838See eligibility →

Recruiting nowPhase 3

A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

Obesity, Overweight and/or ObesityCondition

PF-08653944, PlaceboTreatment

Brazil, Canada50 locations

PfizerSponsor

Updated 2026-09-04 · NCT07595549See eligibility →

Recruiting nowPhase 4

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Psoriasis, Overweight or ObesityCondition

TirzepatideTreatment

United States39 locations

Eli Lilly and CompanySponsor

Updated 2026-09-04 · NCT06857942See eligibility →

Recruiting nowPhase 3

A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight

Overweight, ObesityCondition

Cagrilintide, Placebo cagrilintideTreatment

Greece, Hungary36 locations

Novo Nordisk A/SSponsor

Updated 2026-09-04 · NCT07745504See eligibility →

Recruiting nowPhase 1

A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity

Overweight, ObesityCondition

NNC0721-8060, SemaglutideTreatment

United States2 locations

Novo Nordisk A/SSponsor

Updated 2026-09-04 · NCT07767175See eligibility →

Recruiting nowNot applicable

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Overweight, ObesityCondition

Standard Diet, Ketogenic DietTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-09-04 · NCT06044935See eligibility →

Recruiting nowEarly Phase 1

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

MASLD, ObesityCondition

TirzepatideTreatment

United States1 locations

University of New MexicoSponsor

Updated 2026-09-04 · NCT06934642See eligibility →

Recruiting nowNot applicable

This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder

Autism Spectrum Disorder (ASD), Cardiometabolic Health IndicatorsCondition

Intervention not listedTreatment

United States1 locations

University of VirginiaSponsor

Updated 2026-09-04 · NCT07804680See eligibility →

Recruiting nowPhase 3

A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar

Type 2 DiabetesCondition

Placebo, SurvodutideTreatment

Australia, Canada121 locations

Boehringer IngelheimSponsor

Updated 2026-09-03 · NCT07754461See eligibility →

Recruiting nowPhase 3

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

Obesity, OverweightCondition

Maridebart cafraglutide, PlaceboTreatment

Australia, Japan87 locations

AmgenSponsor

Updated 2026-09-03 · NCT07684235See eligibility →

Recruiting nowPhase 2

A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight

Obesity, OverweightCondition

BI 3034701, Placebo matching BI 3034701Treatment

Australia, Canada54 locations

Boehringer IngelheimSponsor

Updated 2026-09-03 · NCT07662122See eligibility →

Recruiting nowPhase 2

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

Obesity, OverweightCondition

ABBV-295, PlaceboTreatment

Puerto Rico, United States38 locations

AbbVieSponsor

Updated 2026-09-03 · NCT07752979See eligibility →

Recruiting nowPhase 3

Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

Obesity, OverweightCondition

Maridebart Cafraglutide, PlaceboTreatment

Japan, Puerto Rico37 locations

AmgenSponsor

Updated 2026-09-03 · NCT07684144See eligibility →

Recruiting nowNot applicable

New Heart Imaging Techniques to Evaluate Possible Heart Disease

Healthy, ObesityCondition

MR Imaging Techniques - 1, MR Imaging Techniques - 2Treatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-09-03 · NCT01399385See eligibility →

Recruiting nowNot applicable

International Rapid-onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic Dysregulation (ROHHAD) Registry

ROHHAD, Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation & Autonomic DysregulationCondition

ROHHADTreatment

United States1 locations

Ilya KhaytinSponsor

Updated 2026-09-03 · NCT03135730See eligibility →

Recruiting nowEarly Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Hypertension, ObesityCondition

Neuropeptide YTreatment

United States1 locations

University of Texas Southwestern Medical CenterSponsor

Updated 2026-09-03 · NCT04838678See eligibility →

Recruiting nowNot applicable

Ketogenic Diet and Diabetes Demonstration Project

Type 2 Diabetes, PreDiabetesCondition

Ketogenic diet, Low Fat dietTreatment

United States1 locations

University of New MexicoSponsor

Updated 2026-09-03 · NCT06115265See eligibility →

Recruiting nowPhase 1

Alpelisib Challenge Test (ACT)

Insulin Resistance, Type 2 DiabetesCondition

Alpelisib 300 mg, Alpelisib Challenge Test (ACT): Mixed Meal Tolerance Test (MMTT) after taking alpelisibTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-09-03 · NCT07778524See eligibility →

Recruiting nowNot applicable

Effects of Obesity in the Aged

Obesity, AgingCondition

Mechanical unloading of the Thorax using an external cuirassTreatment

United States1 locations

University of Texas Southwestern Medical CenterSponsor

Updated 2026-09-02 · NCT05028309See eligibility →

Recruiting nowPhase 2

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Overweight, Overweight and ObesityCondition

Counseling, Text MessagesTreatment

United States1 locations

Memorial Sloan Kettering Cancer CenterSponsor

Updated 2026-09-02 · NCT05770570See eligibility →

Recruiting nowNot applicable

Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure

Hypertension (Without Type 2 Diabetes Mellitus), High Blood PressureCondition

Wild Blueberry, PlaceboTreatment

United States1 locations

Georgia State UniversitySponsor

Updated 2026-09-02 · NCT06735599See eligibility →

Recruiting nowNot applicable

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), FemaleCondition

Wild Blueberry, PlaceboTreatment

United States1 locations

Georgia State UniversitySponsor

Updated 2026-09-02 · NCT06735651See eligibility →

Recruiting nowPhase 3

Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth

Pediatric Obesity, Metabolic and Bariatric SurgeryCondition

Semaglutide 2.4 mgTreatment

United States1 locations

Children's Hospital Los AngelesSponsor

Updated 2026-09-02 · NCT06934655See eligibility →

Recruiting nowNot applicable

Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation

Drug Discontinuation, Substance Use DisordersCondition

Discontinuation and Reinitiation of TirzepatideTreatment

United States1 locations

The University of Texas at DallasSponsor

Updated 2026-09-02 · NCT07387796See eligibility →

Recruiting nowPhase 3

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Obesity, OverweightCondition

aleniglipron, aleniglipronTreatment

United States74 locations

Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure TherapeuticsSponsor

Updated 2026-09-01 · NCT07654374See eligibility →

Recruiting nowPhase 3

Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

ObesityCondition

Ribupatide, SemaglutideTreatment

Australia, Bulgaria59 locations

KaileraSponsor

Updated 2026-09-01 · NCT07284979See eligibility →

Recruiting nowPhase 2

A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity

Adults With Overweight/Obesity and Type 2 DiabetesCondition

AT673 low dose, AT673 high doseTreatment

United States8 locations

Antag TherapeuticsSponsor

Updated 2026-09-01 · NCT07724340See eligibility →

Recruiting nowNot applicable

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Metabolic Disease, ObesityCondition

NSR IDE-MRI: Research pulse sequencesTreatment

United States3 locations

National Heart, Lung, and Blood Institute (NHLBI)Sponsor

Updated 2026-09-01 · NCT01143454See eligibility →

Recruiting nowPhase 1

A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Obesity, OverweightCondition

LY4174794, LY4174794Treatment

Singapore, United States3 locations

Eli Lilly and CompanySponsor

Updated 2026-09-01 · NCT07654972See eligibility →

Recruiting nowNot applicable

HealthyTogether: RCT of a Dyadic Weight Management Intervention

Obesity, OverweightCondition

HealthyTogetherTreatment

United States2 locations

VA Office of Research and DevelopmentSponsor

Updated 2026-09-01 · NCT06619041See eligibility →

Recruiting nowNot applicable

Physical and Behavioral Traits of Overweight and Obese Adults

Obesity, Healthy VolunteersCondition

Intervention not listedTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-09-01 · NCT00428987See eligibility →

Recruiting nowNot applicable

Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

Cardiovascular Disease, ObesityCondition

Intervention not listedTreatment

United States1 locations

National Heart, Lung, and Blood Institute (NHLBI)Sponsor

Updated 2026-09-01 · NCT01927783See eligibility →

Recruiting nowNot applicable

Children s Growth and Behavior Study

Obesity, Eating BehaviorsCondition

Intervention not listedTreatment

United States1 locations

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Sponsor

Updated 2026-09-01 · NCT02390765See eligibility →

Recruiting nowNot applicable

Investigating the Impact of Obesity on Pubertal Development in Girls

Obesity, PubertyCondition

Intervention not listedTreatment

United States1 locations

National Institute of Environmental Health Sciences (NIEHS)Sponsor

Updated 2026-09-01 · NCT02583646See eligibility →

Recruiting nowPhase 2

Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

Healthy Volunteers, OverweightCondition

Sucralose, PlaceboTreatment

United States1 locations

National Institute on Alcohol Abuse and Alcoholism (NIAAA)Sponsor

Updated 2026-09-01 · NCT03407079See eligibility →

Recruiting nowNot applicable

Early Tracking of Childhood Health Determinants (ETCHED) Study

Diabetes Mellitus, ObesityCondition

Intervention not listedTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-09-01 · NCT03481829See eligibility →

Recruiting nowPhase 1, Phase 2

The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function

Obesity, Metabolic SyndromeCondition

Empagliflozin 25 MG, PlaceboTreatment

United States1 locations

Vanderbilt University Medical CenterSponsor

Updated 2026-09-01 · NCT05972564See eligibility →

Recruiting nowNot applicable

Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity

Adequate Vitamin C Status, Inadequate Vitamin C StatusCondition

Vitamin C Supplement + Low Vitamin C Diet, Placebo + Low Vitamin C DietTreatment

United States1 locations

Ohio State UniversitySponsor

Updated 2026-09-01 · NCT07151105See eligibility →

Recruiting nowNot applicable

Healthy Children, Healthy Communities: Effectiveness of a Multilevel Rural Community Engagement Model for Improving Children's Dietary Intake in Family Child Care Homes

Childhood Obesity Pevention, Diet QualityCondition

EAT Family Style, Better Kid CareTreatment

United States1 locations

University of Nebraska LincolnSponsor

Updated 2026-09-01 · NCT07160530See eligibility →

Recruiting nowNot applicable

BRIDGE & Friends Trial

Obesity & OverweightCondition

Social Network CurriculumTreatment

United States1 locations

University of Illinois at ChicagoSponsor

Updated 2026-09-01 · NCT07798557See eligibility →

Recruiting nowNot applicable

Concurrent Laparoscopic Hysterectomy and Weight Loss Surgery in Obese Patients With Endometrial Carcinoma or Endometrial Intraepithelial Neoplasia

Endometrial Carcinoma, ObesityCondition

CONCURRENT LAPAROSCOPIC HYSTERECTOMY AND WEIGHT LOSS SURGERY-ReferralTreatment

United States2 locations

Dana-Farber Cancer InstituteSponsor

Updated 2026-08-31 · NCT04839614See eligibility →

Recruiting nowNot applicable

Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

ObesityCondition

Step it Up mobile app, Global Positioning System (GPS) DeviceTreatment

United States1 locations

National Heart, Lung, and Blood Institute (NHLBI)Sponsor

Updated 2026-08-31 · NCT03288207See eligibility →

Recruiting nowPhase 4

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Pre-diabetes, ObesityCondition

Mirabegron 50 MG, Tadalafil 10 MGTreatment

United States1 locations

Philip KernSponsor

Updated 2026-08-31 · NCT05051436See eligibility →

Recruiting nowPhase 3

Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome

PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, ObeseCondition

Semaglutide Injectable Product (Wegovy and/or Ozempic)Treatment

United States1 locations

University of Colorado, DenverSponsor

Updated 2026-08-31 · NCT05819853See eligibility →

Recruiting nowPhase 2

GLP-1R Agonist Treatment for Opioid Use Disorder

Opioid Use Disorder, Opioid Abuse and AddictionCondition

Semaglutide Pen Injector, PlaceboTreatment

United States4 locations

Milton S. Hershey Medical CenterSponsor

Updated 2026-08-28 · NCT06548490See eligibility →

Recruiting nowNot applicable

An Online Intuitive Eating Program for Pregnant Women With Obesity to Support Well-Being

Excessive Gestational Weight Gain, PregnancyCondition

Intuitive Eating InterventionTreatment

United States2 locations

San Diego State UniversitySponsor

Updated 2026-08-28 · NCT07792837See eligibility →

Recruiting nowNot applicable

Diabetes and Heart Disease Risk in Blacks

Cardiovascular Diseases, DiabetesCondition

Intervention not listedTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-08-28 · NCT00001853See eligibility →

Recruiting nowNot applicable

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

Obesity, Normal PhysiologyCondition

+200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fastingTreatment

United States1 locations

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sponsor

Updated 2026-08-28 · NCT05545306See eligibility →

Recruiting nowNot applicable

Effects of Watermelon or Low-fat Cookie Consumption on Wellness

Overweight and ObesityCondition

Low-fat cookies, WatermelonTreatment

United States1 locations

San Diego State UniversitySponsor

Updated 2026-08-28 · NCT06323070See eligibility →

Recruiting nowPhase 4

Tirzepatide in Idiopathic Intracranial Hypertension Trial

Idiopathic Intracranial Hypertension (IIH)Condition

Tirzepatide, Tirzepatide PlaceboTreatment

United States1 locations

Duke UniversitySponsor

Updated 2026-08-28 · NCT07191873See eligibility →

Recruiting nowPhase 3

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Obesity or OverweightCondition

Maridebart CafraglutideTreatment

Puerto Rico, United States45 locations

AmgenSponsor

Updated 2026-08-27 · NCT07575399See eligibility →

Recruiting nowPhase 4

GLP-1R Actions on Muscle and the Skeleton

Musculoskeletal Abnormalities, ObesityCondition

Tirzepatide, Lifestyle toolkitTreatment

United States2 locations

Pennington Biomedical Research CenterSponsor

Updated 2026-08-27 · NCT07154719See eligibility →

Recruiting nowNot applicable

Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

Overweight (BMI > 25), Obesity (BMI>30)Condition

Avocado, ControlTreatment

United States2 locations

Midwest Center for Metabolic and Cardiovascular ResearchSponsor

Updated 2026-08-27 · NCT07566325See eligibility →

Recruiting nowNot applicable

PPDTM CorEvitasTM Obesity (OBR) Drug Effectiveness and Safety Registry

ObesityCondition

Biospecimen collectionTreatment

United States1 locations

CorEvitasSponsor

Updated 2026-08-27 · NCT07598981See eligibility →

This page shows the first 60 studies. Use the full search to filter all matches.

Related countries

China326 Canada158 France110 Spain98 Germany95

How current is this page?

The page is rebuilt from the public registry feed. Each trial card shows the registry update date. Recruitment can still change between builds.

Does appearing here mean I qualify?

No. These pages are discovery indexes. Only a study team can confirm eligibility after reviewing the complete protocol criteria.