Clinical trial

Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity

Recruiting now · Not applicable · 1 countries · Registry ID NCT07702825

Recruiting nowNot applicableObservational

What this study is about

The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age12 Years to 18 Years

SexAll

Healthy volunteersNot accepted

ConditionChildhood Obesity

Full registry criteria

Inclusion Criteria: * Age 12 to \<18 years at the time of enrolment * BMI \>99.6th centile or \>2.67 SDS * Informed consent from parent(s) (or person with parental responsibility) and assent from the child or young person for participants aged less than 16 years (or) * Informed consent from the participant if aged ≥ 16 years. Exclusion Criteria: * Body weight above upper limit of the scanner (\>250 kilograms) * Needs general anaesthesia for the MRI scanning * Any contraindications for MRI- Metal implants/claustrophobia * Previous use of GLP-1 receptor agonist * Refusal to consent or refusal to assent from a competent older adolescent.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Change in Liver fat measured using quantitative MRIFrom enrollment to 9 months

Change in liver fat content from baseline to follow-up, quantified using MRI-derived proton density fat fraction (PDFF).

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Alder Hey Children's hospital🇬🇧 Liverpool, Merseyside, United Kingdom

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Anand Ramakrishnan, MBBS, MD, MRCPCH, DipUKMPContact

Email · Call 07404613764