Phase

EARLY_PHASE1 clinical trials

Active studies categorized as EARLY_PHASE1 in the public registry.

34active studies

19recruiting now

10countries represented

7largest site network

Current studies

Status and location data reflect the registry snapshot built 2026-09-08. Verify the original record before contacting a site.

Recruiting nowEarly Phase 1

Effect of Tirzepatide on Markers of MASLD in Patients With Obesity

MASLD, ObesityCondition

TirzepatideTreatment

United States1 locations

University of New MexicoSponsor

Updated 2026-09-04 · NCT06934642See eligibility →

Recruiting nowEarly Phase 1

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Hypertension, ObesityCondition

Neuropeptide YTreatment

United States1 locations

University of Texas Southwestern Medical CenterSponsor

Updated 2026-09-03 · NCT04838678See eligibility →

Recruiting nowEarly Phase 1

Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity

Osteoarthritis (OA) of the KneeCondition

Metformin, PlaceboTreatment

Hong Kong1 locations

The University of Hong KongSponsor

Updated 2026-08-18 · NCT07065591See eligibility →

Recruiting nowEarly Phase 1

A Single and Multiple Ascending Dose Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP6590 in Participants With Normal Weight, Overweight and Obesity

Healthy Participants Study, Overweight and Obese AdultsCondition

ZP6590, solution for injection, Placebo, solution for injectionTreatment

Germany1 locations

Zealand PharmaSponsor

Updated 2026-08-13 · NCT07721597See eligibility →

Recruiting nowEarly Phase 1

Induction of Labor in Morbidly Obese Patients

Morbid Obesity, PregnancyCondition

MisoprostolTreatment

United States1 locations

University of Maryland, BaltimoreSponsor

Updated 2026-07-29 · NCT06199154See eligibility →

Recruiting nowEarly Phase 1

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Obesity, VasodilationCondition

Propranolol Hydrochloride, IsoproterenolTreatment

United States1 locations

University of Missouri-ColumbiaSponsor

Updated 2026-07-28 · NCT05219799See eligibility →

Recruiting nowEarly Phase 1

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

ObesityCondition

Somatostatin, EpinephrineTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-05-22 · NCT06416969See eligibility →

Recruiting nowEarly Phase 1

Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

Obesity and Obesity-related Medical ConditionsCondition

Mounjaro, Sleeve GastrectomyTreatment

United States1 locations

Nicholas SkertichSponsor

Updated 2026-05-08 · NCT06734273See eligibility →

Recruiting nowEarly Phase 1

ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study

Overweight and ObesityCondition

Inhalation - Natural Odour, Inhalation - PlaceboTreatment

Switzerland2 locations

University Hospital, Basel, SwitzerlandSponsor

Updated 2026-05-04 · NCT06370845See eligibility →

Recruiting nowEarly Phase 1

Tirzepatide in Obesity-Driven Endometrial Cancer

Endometrial Cancer, ObesityCondition

TirzepatideTreatment

United States1 locations

UNC Lineberger Comprehensive Cancer CenterSponsor

Updated 2026-04-28 · NCT07065552See eligibility →

Recruiting nowEarly Phase 1

A Study of a Weight Loss Intervention in People With Endometrial Cancer

Endometrial CancerCondition

TirzepatideTreatment

United States7 locations

Memorial Sloan Kettering Cancer CenterSponsor

Updated 2026-04-13 · NCT06751589See eligibility →

Recruiting nowEarly Phase 1

Regional Lipolysis Insulin Regulation

ObesityCondition

InsulinTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-04-13 · NCT06392854See eligibility →

Recruiting nowEarly Phase 1

Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study

Diabetes, Prostate CancerCondition

TirzepatideTreatment

United States1 locations

M.D. Anderson Cancer CenterSponsor

Updated 2026-02-27 · NCT06759701See eligibility →

Recruiting nowEarly Phase 1

Crocus Sativus Tepals Water Extract in Obesity and Prediabetes

Prediabetes, Obesity & OverweightCondition

Crocus sativus tepals cold aqueous extract, cold waterTreatment

Slovenia1 locations

University of PrimorskaSponsor

Updated 2026-02-04 · NCT07261475See eligibility →

Recruiting nowEarly Phase 1

Insulin Regulation of Lipolysis and Lipolysis Proteins

ObesityCondition

Immediate weight loss, PioglitazoneTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-01-28 · NCT03866408See eligibility →

Recruiting nowEarly Phase 1

GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab

Type 1 DiabetesCondition

Semaglutide (Rybelsus®), PlaceboTreatment

United States1 locations

Vanderbilt University Medical CenterSponsor

Updated 2025-12-18 · NCT06338553See eligibility →

Recruiting nowEarly Phase 1

Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension

Obesity, HypertensionCondition

Angiotensin-(1-7), SalineTreatment

United States1 locations

Milton S. Hershey Medical CenterSponsor

Updated 2025-09-19 · NCT06482853See eligibility →

Recruiting nowEarly Phase 1

Akkermansia Muciniphilia and Metabolic Side Effects of ADT

Prostate Cancer, Metabolic SyndromeCondition

Apple Cider VinegarTreatment

Canada1 locations

Western UniversitySponsor

Updated 2025-08-20 · NCT05802121See eligibility →

Recruiting nowEarly Phase 1

Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

LymphedemaCondition

GLP-1 Receptor AgonistsTreatment

United States2 locations

Advanced Reconstructive Surgery AllianceSponsor

Updated 2025-06-10 · NCT07012642See eligibility →

Opening soonEarly Phase 1

Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health

Hypertension (HTN), Diabetes (DM)Condition

Team-based shared decision-makingTreatment

Locations pending0 locations

Johns Hopkins UniversitySponsor

Updated 2026-08-12 · NCT07662616See eligibility →

Opening soonEarly Phase 1

Qing-Xin-Jiao-Tai Decoction for Insomnia Comorbid With Obesity Presenting With Heart-Kidney Non-interaction Syndrome

Insomnia, ObesityCondition

Qingxin Jiaotai Decoction, PlaceboTreatment

China1 locations

Fohow Pharmaceutical GroupSponsor

Updated 2026-08-10 · NCT07754383See eligibility →

Opening soonEarly Phase 1

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Obesity (BMI>30), Insulin ResistanceCondition

human insulinTreatment

United States1 locations

University of Missouri-ColumbiaSponsor

Updated 2026-07-28 · NCT07653464See eligibility →

Opening soonEarly Phase 1

Preoperative Semaglutide Prior to Radical Prostatectomy

Prostate CancerCondition

Semaglutide 2.4 mgTreatment

United States1 locations

Banner HealthSponsor

Updated 2026-07-27 · NCT07727473See eligibility →

Opening soonEarly Phase 1

GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer

Pancreatic Cancer, Colorectal CancerCondition

GLP1-RA (semaglutide)Treatment

United States1 locations

University of ArizonaSponsor

Updated 2026-07-02 · NCT07627191See eligibility →

Opening soonEarly Phase 1

Chronic Intervention With Sulforaphane-Smart® in Overweight and Obese Adults

Obesity and OverweightCondition

Sulforaphan-Smart® formula, Control (placebo) groupTreatment

Spain1 locations

Mª Jesús PeriagoSponsor

Updated 2025-05-09 · NCT06964659See eligibility →

Invitation onlyEarly Phase 1

Truway Diagnostic Tools in Primary Care

Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, OverweightCondition

Truway Portable Ultrasound Device, Truway Blood Glucose MonitorTreatment

United States1 locations

Truway Health, Inc.Sponsor

Updated 2025-10-24 · NCT07209527See eligibility →

Invitation onlyEarly Phase 1

Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures

Longevity, Quality of LifeCondition

GLP-1, PlaceboTreatment

United States1 locations

AgelessRxSponsor

Updated 2025-07-30 · NCT07092605See eligibility →

Active, not recruitingEarly Phase 1

Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist

Osteoarthritis (OA) of the KneeCondition

Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)Treatment

Hong Kong1 locations

The University of Hong KongSponsor

Updated 2026-08-19 · NCT06807970See eligibility →

Active, not recruitingEarly Phase 1

L. Acidophilus (Strain TW01) on Gut Health, Body Composition, and Inflammation

Overweight (BMI > 25), Obese, Otherwise Healthy VolunteersCondition

Placebo, ProbioticTreatment

United States1 locations

University of ConnecticutSponsor

Updated 2026-08-13 · NCT06912100See eligibility →

Active, not recruitingEarly Phase 1

Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity

Dyslipidemias, ObesityCondition

Milk Polar Lipid-Rich Dairy Powder, Dairy PowderTreatment

United States1 locations

University of ConnecticutSponsor

Updated 2026-08-12 · NCT05700916See eligibility →

Active, not recruitingEarly Phase 1

Phentermine/Topiramate in Adolescents With Type 2 Diabetes and Obesity

Pediatric ObesityCondition

Phentermine/Topiramate (Qsymia), PlaceboTreatment

United States1 locations

University of MinnesotaSponsor

Updated 2026-05-22 · NCT04881799See eligibility →

Active, not recruitingEarly Phase 1

A Trial of HRS-5817 in Obese Participants

ObesityCondition

HRS-5817, HRS-5817Treatment

Australia1 locations

Atridia Pty Ltd.Sponsor

Updated 2026-05-12 · NCT07238647See eligibility →

Active, not recruitingEarly Phase 1

Angiotensin-(1-7) and Energy Expenditure in Human Obesity

ObesityCondition

Angiotensin-(1-7), SalineTreatment

United States1 locations

Amy ArnoldSponsor

Updated 2025-09-19 · NCT03777215See eligibility →

Active, not recruitingEarly Phase 1

Aerobic Versus Resistance Exercises on Insulin Sensitivity in Obese Patients

Insulin Sensitivity/ResistanceCondition

MetforminTreatment

Egypt1 locations

Cairo UniversitySponsor

Updated 2025-01-14 · NCT06772857See eligibility →

How current is this page?

The page is rebuilt from the public registry feed. Each trial card shows the registry update date. Recruitment can still change between builds.

Does appearing here mean I qualify?

No. These pages are discovery indexes. Only a study team can confirm eligibility after reviewing the complete protocol criteria.

EARLY_PHASE1 clinical trials

Current studies

Related phases