Clinical trial

Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Recruiting now · Early Phase 1 · 1 countries · Registry ID NCT04838678

Recruiting nowEarly Phase 1Interventional

What this study is about

The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 55 Years

SexAll

Healthy volunteersAccepted

ConditionHypertension, Obesity

Full registry criteria

Inclusion Criteria: * Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Exclusion Criteria: All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,

Treatments and study arms

Neuropeptide Y

Drug

intra-arterial infusion of neuropeptide Y

Primary outcomes

Blood flow measured by doppler ultrasoundAcutely on the day of study

brachial and femoral artery blood flow

Muscle sympathetic nervous system activityAcutely on the day of study

recording of sympathetic nervous system activity from the peroneal or radial nerve

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Texas Southwestern Medical Center🇺🇸 Dallas, Texas, United States

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CHristopher HearonContact

Email · Call 8155405612