Clinical trial

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Recruiting now · Early Phase 1 · 1 countries · Registry ID NCT05219799

Recruiting nowEarly Phase 1Interventional

What this study is about

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 45 Years

SexAll

Healthy volunteersAccepted

ConditionObesity, Vasodilation, Healthy

Full registry criteria

Inclusion Criteria: * BMI \>18 kg/m2 Exclusion Criteria: * Pregnancy, breastfeeding * Diagnosed sleep apnea or AHI \>10 events/hr * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications, Sensitivity to lidocaine

Treatments and study arms

Propranolol Hydrochloride

Drug

Regional forearm blockade of β-adrenergic receptors at 20 mcg/dL/min via brachial artery catheter during normoxia and hypoxia exposures

Isoproterenol

Drug

Dose response (1, 3, 6, and 12 ng/dL/min) regional infusion to assess β-adrenergic receptor responsiveness

Phentolamine Mesylate

Drug

This infusion will be for 10 min before baseline measurement (12 mcg/dL/min) and continue the infusion at a maintenance rate (5 mcg/dL/min).

Norepinephrine

Drug

Regional forearm infusion at 8 ng/dL/min via brachial artery catheter during normoxia and hypoxia exposures

Primary outcomes

Change in forearm vascular conductance with intra-arterial drug infusionChange from baseline to last 1-minute of drug infusion

Vascular conductance is an index of vascular tone and is measured using a technique called venous occlusion plethysmography.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Missouri🇺🇸 Columbia, Missouri, United States

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Jennifer L HarperContact

Email · Call 5738822544