Clinical trial

Aerobic Versus Resistance Exercises on Insulin Sensitivity in Obese Patients

Active, not recruiting · Early Phase 1 · 1 countries · Registry ID NCT06772857

Active, not recruitingEarly Phase 1Interventional

What this study is about

The purpose of study is to compare the effect of different exercise modes on insulin resistance and body composition in obese patients.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age30 Years to 40 Years

SexAll

Healthy volunteersAccepted

ConditionInsulin Sensitivity/Resistance

Full registry criteria

Inclusion Criteria: * Sixty obese prediabetic patients from both sexes with ages ranging from 30 to 40 years old. * Body mass index (BMI) ranging from 30 to 34.9 kg/m². * Insulin resistance as assessed by the homeostasis model assessment for insulin resistance (HOMA-IR) levels above 1.9. * Blood glucose levels ranging from 100 to 125 mg/dL (5.6-6.9 mmol/L). * Patients will receive the same medical and diet regimen, with instructions not to change their physical activity during the study. * HbA1c levels between 6.0% and 6.5%, indicating high risk for diabetes and possible consideration for prevention interventions. Exclusion Criteria: * Uncontrolled diabetes. * Uncontrolled hypertension. * Cardiovascular disease. * Respiratory disease. * Hepatic disease. * Severe life-limiting illness (e.g., cancer). * Use of weight loss medications. * Orthopedic or neurological disorders that limit exercise participation. * Endocrine disorders. * Kidney disease.

Treatments and study arms

Metformin

Drug

Metformin is a drug used to manage blood glucose levels. It improves insulin sensitivity and reduces glucose production in the liver. This regimen will be provided to all study groups (A, B, and C) in combination with the respective interventions described for each group. Participants are instructed not to change their physical activity during the study.

Primary outcomes

Change in Insulin Resistance Between Different Exercise Modes in Obese Patients3months

The change in insulin resistance will be assessed using the HOMA-IR index in obese patients after different exercise interventions (aerobic vs resistance) compared to baseline. The HOMA-IR index will be calculated based on fasting blood glucose and fasting insulin levels, which are widely accepted measures of insulin resistance.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Cairo University🇪🇬 Cairo, Egypt

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