Phase

PHASE4 clinical trials

Active studies categorized as PHASE4 in the public registry.

157active studies

76recruiting now

36countries represented

140largest site network

Current studies

Status and location data reflect the registry snapshot built 2026-09-08. Verify the original record before contacting a site.

Recruiting nowPhase 4

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Psoriatic Arthritis, Overweight or ObesityCondition

TirzepatideTreatment

Puerto Rico, United States55 locations

Eli Lilly and CompanySponsor

Updated 2026-09-08 · NCT06864026See eligibility →

Recruiting nowPhase 4

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Psoriasis, Overweight or ObesityCondition

TirzepatideTreatment

United States39 locations

Eli Lilly and CompanySponsor

Updated 2026-09-04 · NCT06857942See eligibility →

Recruiting nowPhase 4

The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

Pre-diabetes, ObesityCondition

Mirabegron 50 MG, Tadalafil 10 MGTreatment

United States1 locations

Philip KernSponsor

Updated 2026-08-31 · NCT05051436See eligibility →

Recruiting nowPhase 4

Tirzepatide in Idiopathic Intracranial Hypertension Trial

Idiopathic Intracranial Hypertension (IIH)Condition

Tirzepatide, Tirzepatide PlaceboTreatment

United States1 locations

Duke UniversitySponsor

Updated 2026-08-28 · NCT07191873See eligibility →

Recruiting nowPhase 4

GLP-1R Actions on Muscle and the Skeleton

Musculoskeletal Abnormalities, ObesityCondition

Tirzepatide, Lifestyle toolkitTreatment

United States2 locations

Pennington Biomedical Research CenterSponsor

Updated 2026-08-27 · NCT07154719See eligibility →

Recruiting nowPhase 4

Incretin Therapies in Obesity-related HFpEF

Heart Failure, Diastolic, Heart Failure With Preserved Ejection FractionCondition

TirzepatideTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-08-24 · NCT07554638See eligibility →

Recruiting nowPhase 4

The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

Obesity, Menopause Hot FlashesCondition

Tirzepatide, PlaceboTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-08-18 · NCT07218445See eligibility →

Recruiting nowPhase 4

Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction

Heart Failure Preserved Ejection Fraction, Epicardial Adipose TissueCondition

GLP-1RATreatment

United States1 locations

University of VirginiaSponsor

Updated 2026-08-11 · NCT07178145See eligibility →

Recruiting nowPhase 4

Impact of Glucagon-like Peptide-1 (GLP-1) Analogs on Disease Outcomes in Psoriatic Arthritis: A Pragmatic Randomized Controlled Trial

Psoriatic Arthritis (PsA)Condition

GLP-1 agonists, Nutrition CounselingTreatment

United States1 locations

Medical College of WisconsinSponsor

Updated 2026-08-10 · NCT07111494See eligibility →

Recruiting nowPhase 4

Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study

Atrial Fibrillation (AF), Obesity & OverweightCondition

Semaglutide 2.4 mg, Standard medical treatmentTreatment

Sweden1 locations

Emma SvennbergSponsor

Updated 2026-08-10 · NCT07275697See eligibility →

Recruiting nowPhase 4

Fibrosis Lessens After Metabolic Surgery

Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver DiseaseCondition

Metabolic surgery, Incretin-Based TherapyTreatment

Brazil, Canada22 locations

The Cleveland ClinicSponsor

Updated 2026-07-31 · NCT06374875See eligibility →

Recruiting nowPhase 4

A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity

Obesity & OverweightCondition

Semaglutide 6 mg liquid emulsion formulation, Wegovy® (semaglutide) TabletTreatment

United States1 locations

Gila Therapeutics, Inc.Sponsor

Updated 2026-07-27 · NCT07728383See eligibility →

Recruiting nowPhase 4

Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors

Obesity (Disorder), Breast CancerCondition

TirzepatideTreatment

United States1 locations

Weill Medical College of Cornell UniversitySponsor

Updated 2026-07-22 · NCT07257484See eligibility →

Recruiting nowPhase 4

GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH

Genetic Predisposition, Metabolic DiseasesCondition

oral semaglutide, Mixed Meal Tolerance Test (MMTT)Treatment

United States1 locations

Massachusetts General HospitalSponsor

Updated 2026-07-08 · NCT06003153See eligibility →

Recruiting nowPhase 4

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

ObesityCondition

Tirzepatide, Standard of CareTreatment

United Kingdom30 locations

Eli Lilly and CompanySponsor

Updated 2026-07-07 · NCT07247084See eligibility →

Recruiting nowPhase 4

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity, Chronic Kidney DiseaseCondition

Semaglutide, Virtual Weight Management CoachingTreatment

Canada1 locations

Western University, CanadaSponsor

Updated 2026-06-29 · NCT06396416See eligibility →

Recruiting nowPhase 4

Real-World Effects of MC4R Agonist Therapy in BBS and Severe Genetic Obesity

Bardet Biedl Syndrome (BBS), Bardet Biedl SyndromeCondition

SetmelanotideTreatment

Germany1 locations

Tom HühneSponsor

Updated 2026-06-29 · NCT07674290See eligibility →

Recruiting nowPhase 4

Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis

Kidney Disease, Chronic, DiabetesCondition

Semaglutide PenTreatment

Canada2 locations

Unity Health TorontoSponsor

Updated 2026-06-26 · NCT07017270See eligibility →

Recruiting nowPhase 4

Weight Loss Study: Genetics and Response to Naltrexone/Bupropion

ObesityCondition

Naltrexone-Bupropion CombinationTreatment

United States1 locations

Columbia UniversitySponsor

Updated 2026-06-10 · NCT05919797See eligibility →

Recruiting nowPhase 4

The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass

Obesity, Gastric RefluxCondition

upper endoscopyTreatment

Switzerland1 locations

Prof Urs ZinggSponsor

Updated 2026-06-09 · NCT05320796See eligibility →

Recruiting nowPhase 4

Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery

ObesityCondition

Topiramate, PhentermineTreatment

United States1 locations

University of California, IrvineSponsor

Updated 2026-06-09 · NCT05975580See eligibility →

Recruiting nowPhase 4

Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.

Obesity, Diabetes Mellitus, Type 2Condition

Tirzepatide (LIPOLESS de Laboratorio de Productos Eticos C.E.I.S.A.)Treatment

Paraguay1 locations

Las Rías Medical CenterSponsor

Updated 2026-05-19 · NCT07588438See eligibility →

Recruiting nowPhase 4

2024 Tirzepatide-Bariatric Surgery

Obesity and Obesity-related Medical Conditions, Bariatric SurgeryCondition

tirzepatide, Standard of CareTreatment

United States1 locations

Marlene StarrSponsor

Updated 2026-05-14 · NCT06721507See eligibility →

Recruiting nowPhase 4

Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Condition

Oral semaglutide, Empagliflozin 10 mgTreatment

Slovenia1 locations

University Medical Centre LjubljanaSponsor

Updated 2026-04-30 · NCT06613854See eligibility →

Recruiting nowPhase 4

Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes

Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)Condition

GLP-1 Receptor AgonistsTreatment

China1 locations

The First Affiliated Hospital with Nanjing Medical UniversitySponsor

Updated 2026-04-30 · NCT07558863See eligibility →

Recruiting nowPhase 4

Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System

Obesity, Morbid, AnesthesiaCondition

Propofol, PropofolTreatment

India1 locations

Sir Ganga Ram HospitalSponsor

Updated 2026-04-27 · NCT05305313See eligibility →

Recruiting nowPhase 4

Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide

Diabetes Mellitus, Type 2, DiabetesCondition

Insulin resistance testing, OGTTTreatment

United States2 locations

Stanford UniversitySponsor

Updated 2026-04-20 · NCT06657209See eligibility →

Recruiting nowPhase 4

Tirzepatide Use in People With Obesity and Type 1 Diabetes

Type1diabetes, ObesityCondition

Tirzepatide, PlaceboTreatment

Kuwait1 locations

Dasman Diabetes InstituteSponsor

Updated 2026-04-20 · NCT07096908See eligibility →

Recruiting nowPhase 4

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

Type2Diabetes, ASCVDCondition

SGLT2 inhibitor, GLP-1 receptor agonistTreatment

United States36 locations

Brigham and Women's HospitalSponsor

Updated 2026-04-13 · NCT05390892See eligibility →

Recruiting nowPhase 4

Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes

Spinal Cord Injuries, Type 2 DiabetesCondition

Semaglutide Injectable Product, PlaceboTreatment

United States2 locations

Marzieh SalehiSponsor

Updated 2026-04-13 · NCT06706284See eligibility →

Recruiting nowPhase 4

Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults

Obesity, Weight ReductionCondition

Locally available low-dose semaglutide (0.25 mg, 0.5 mg, 1 mg)Treatment

Pakistan1 locations

Asian Institute Of Medical SciencesSponsor

Updated 2026-04-06 · NCT07513168See eligibility →

Recruiting nowPhase 4

The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM), SemaglutideCondition

semaglutide, caloric restrictionTreatment

China1 locations

Second Affiliated Hospital of Nanchang UniversitySponsor

Updated 2026-04-02 · NCT07272343See eligibility →

Recruiting nowPhase 4

Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability

Intellectual Disability, Developmental DisabilityCondition

Metformin, PlaceboTreatment

Canada1 locations

Centre for Addiction and Mental HealthSponsor

Updated 2026-03-31 · NCT05744479See eligibility →

Recruiting nowPhase 4

Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients

Crohn DiseaseCondition

Tirzepatide, Mediterranean dietTreatment

United States1 locations

University of MiamiSponsor

Updated 2026-03-30 · NCT06774079See eligibility →

Recruiting nowPhase 4

Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

PreDiabetesCondition

SemaglutideTreatment

United States1 locations

The University of Texas Health Science Center, HoustonSponsor

Updated 2026-03-17 · NCT05119179See eligibility →

Recruiting nowPhase 4

Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

Bipolar I Disorder, Bipolar II DisorderCondition

Group Therapy Program, semaglutideTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-03-11 · NCT07213466See eligibility →

Recruiting nowPhase 4

Knee Injections for Obese Patients With Knee Arthritis

Osteoarthritis of KneeCondition

Triamcinolone Acetonide Low Dose, Triamcinolone Acetonide Standard DoseTreatment

United States1 locations

Mayo ClinicSponsor

Updated 2026-03-10 · NCT06782529See eligibility →

Recruiting nowPhase 4

Tirzepatide (Spartina) in Obese Kidney Transplant Recipients

TirzepatideCondition

TirzepatideTreatment

Iran1 locations

Shahid Beheshti University of Medical SciencesSponsor

Updated 2026-02-20 · NCT07423247See eligibility →

Recruiting nowPhase 4

Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis

Psoriasis (PsO), Obesity & OverweightCondition

Semaglutide (Rybelsus®), PlaceboTreatment

Mexico1 locations

Hospital Universitario Dr. Jose E. GonzalezSponsor

Updated 2026-02-11 · NCT07401992See eligibility →

Recruiting nowPhase 4

Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity

Major Depressive DisorderCondition

Semaglutide Injectable Product, PlaceboTreatment

Denmark1 locations

Nordsjaellands HospitalSponsor

Updated 2026-02-06 · NCT07136714See eligibility →

Recruiting nowPhase 4

Evaluating Anti-Obesity Medications 6 Months After Metabolic Surgery

Obesity, Weight LossCondition

Efsubaglutide Alfa Injection, Diet and exercise guidelinesTreatment

China1 locations

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolSponsor

Updated 2026-01-27 · NCT07163650See eligibility →

Recruiting nowPhase 4

Impact GLP-1 Agonists Following Bariatric

Morbid Obesity, Metabolic SyndromeCondition

GLP-1 receptor agonistTreatment

United States1 locations

University of Missouri-ColumbiaSponsor

Updated 2026-01-22 · NCT06132477See eligibility →

Recruiting nowPhase 4

Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization.

Infertility, ObesityCondition

Semaglutide, No pre-treatmentTreatment

Spain5 locations

Fundacion DexeusSponsor

Updated 2026-01-21 · NCT07242534See eligibility →

Recruiting nowPhase 4

JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity

Obesity (Disorder)Condition

Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)Treatment

Canada1 locations

McMaster UniversitySponsor

Updated 2026-01-14 · NCT06852391See eligibility →

Recruiting nowPhase 4

A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese

Polycystic Ovary Syndrome (PCOS), Obesity & OverweightCondition

Tirzepatide as an adjunct to lifestyle intervention, Placebo as an adjunct to lifestyle interventionTreatment

Germany2 locations

University of BonnSponsor

Updated 2026-01-08 · NCT07326111See eligibility →

Recruiting nowPhase 4

GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM

T2DM (Type 2 Diabetes Mellitus)Condition

semaglutide, Standard Treatment (Guideline-Based)Treatment

Italy2 locations

Federico II UniversitySponsor

Updated 2026-01-02 · NCT07314684See eligibility →

Recruiting nowPhase 4

Semaglutide Treatment for Hyperglycaemia After Renal Transplantation

Hyperglycemia, Renal Transplant Complication Primary Non-FunctionCondition

Semaglutide 14 MG [Rybelsus], PlaceboTreatment

Denmark1 locations

Rigshospitalet, DenmarkSponsor

Updated 2025-12-29 · NCT05702931See eligibility →

Recruiting nowPhase 4

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

Liver Cirrhoses, Portal Hypertension Related to CirrhosisCondition

Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve GastrectomyTreatment

United States1 locations

The Cleveland ClinicSponsor

Updated 2025-12-23 · NCT07058155See eligibility →

Recruiting nowPhase 4

Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.

Morbid Obesity Requiring Bariatric Surgery, Postoperative PainCondition

Intravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard AnesthesiaTreatment

Mexico2 locations

Instituto Mexicano del Seguro SocialSponsor

Updated 2025-11-28 · NCT07073846See eligibility →

Recruiting nowPhase 4

Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes

Coronary Artery Disease, PreDiabetesCondition

Semaglutide 14 MG [Rybelsus], Dapagliflozin (Forxiga)Treatment

Poland1 locations

National Institute of Cardiology, Warsaw, PolandSponsor

Updated 2025-11-28 · NCT07254572See eligibility →

Recruiting nowPhase 4

Effect of Itopride on Semaglutide Gastroparesis

Semaglutide-Induced Gastric Motility, AnesthesiaCondition

Itopride HCI 50 mg, PlaceboTreatment

Egypt1 locations

Ain Shams UniversitySponsor

Updated 2025-11-28 · NCT07254715See eligibility →

Recruiting nowPhase 4

Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome

Metabolic SyndromeCondition

Semaglutide, Empagliflozin, Minigastric bypassTreatment

Kazakhstan1 locations

University Medical Center, KazakhstanSponsor

Updated 2025-11-26 · NCT06410352See eligibility →

Recruiting nowPhase 4

A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease

Chronic Kidney Disease(CKD)Condition

Dapagliflozin, SemaglutideTreatment

Denmark, Germany4 locations

Peter RossingSponsor

Updated 2025-11-20 · NCT07239570See eligibility →

Recruiting nowPhase 4

Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients

DepressionCondition

Metformin HydrochlorideTreatment

Pakistan2 locations

Fazaia Ruth Pfau Medical CollegeSponsor

Updated 2025-09-19 · NCT06707012See eligibility →

Recruiting nowPhase 4

Tirzepatide in PWS, HO and GNSO

Prader-Willi Syndrome, Hypothalamic ObesityCondition

TirzepatideTreatment

United States3 locations

Grace KimSponsor

Updated 2025-09-16 · NCT06901245See eligibility →

Recruiting nowPhase 4

Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity

Obesity and Type 2 DiabetesCondition

Enavogliflozin, PlaceboTreatment

South Korea1 locations

Korea University Anam HospitalSponsor

Updated 2025-09-02 · NCT06782139See eligibility →

Recruiting nowPhase 4

Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants

Type 2 Diabetes Mellitus in Obese, Heart Failure With Preserved Ejection FractionCondition

Pioglitazone, PlaceboTreatment

United States1 locations

The University of Texas Health Science Center at San AntonioSponsor

Updated 2025-08-27 · NCT05838287See eligibility →

Recruiting nowPhase 4

Impact of Semaglutide on Tobacco Use and Related Health Behaviors

Tobacco UseCondition

Semaglutide, PlaceboTreatment

United States1 locations

University of OklahomaSponsor

Updated 2025-08-27 · NCT06986993See eligibility →

Recruiting nowPhase 4

Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet

Obesity; Drug, Obesity, MorbidCondition

Naltrexone/Bupropion, PlaceboTreatment

Canada1 locations

Laval UniversitySponsor

Updated 2025-08-08 · NCT06620562See eligibility →

Recruiting nowPhase 4

Role of Tranexamic Acid in Reducing Hemorrhagic Events in Bariatric Surgery

Hemorrhage, Bariatric SurgeryCondition

Tranexamic Acid, Normal Saline (Placebo)Treatment

Pakistan1 locations

Patel Hospital, PakistanSponsor

Updated 2025-08-01 · NCT07098780See eligibility →

This page shows the first 60 studies. Use the full search to filter all matches.

How current is this page?

The page is rebuilt from the public registry feed. Each trial card shows the registry update date. Recruitment can still change between builds.

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No. These pages are discovery indexes. Only a study team can confirm eligibility after reviewing the complete protocol criteria.

PHASE4 clinical trials

Current studies

Related phases