Clinical trial

EMS vs. Resistance Training in Overweight Women

Opening soon · Not applicable · 1 countries · Registry ID NCT07787286

Opening soonNot applicableInterventional

What this study is about

This study aims to compare the effects of eight weeks of resistance training versus electrical muscle stimulation (EMS) on oxidative stress indicators and cellular health index in overweight and obese women aged 35-45 years. Forty-two participants will be randomly assigned to three groups: resistance training, EMS, and control. The resistance training group will perform progressive resistance exercises three times per week for eight weeks. The EMS group will receive electrical muscle stimulation on biceps, abdominal, back, and quadriceps muscles three times per week for eight weeks. The control group will receive no intervention. Oxidative stress markers including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), glutathione, protein carbonyl (PC), and total antioxidant capacity (TAC) will be measured from blood samples. Cellular health will be assessed using phase angle (PhA) derived from bioelectrical impedance analysis. Upper and lower body muscular strength and endurance will also be evaluated. All measurements will be taken at baseline and 48 hours after the last training session. The primary outcome is change in phase angle. Secondary outcomes include changes in oxidative stress markers and physical performance.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age35 Years to 45 Years

SexFemale

Healthy volunteersAccepted

ConditionObesity & Overweight

Full registry criteria

Inclusion Criteria: * Healthy non-menopausal women aged 35 to 45 years Body mass index (BMI) between 25 and 35 kg/m² Similar menstrual cycle pattern No pregnancy or lactation No continuous medication affecting fat or muscle mass (based on health and fitness questionnaire) No history of cruciate ligament injury or other upper/lower extremity injuries in the past 6 months No history of heart attack or acute cardiovascular disease No use of medications (glucocorticoids, beta-blockers, alcohol) or antioxidant supplements that could interfere with study results Exclusion Criteria: * Inability to complete the intervention program Absence from more than three consecutive training sessions Failure to comply with the study protocol Development of any medical condition during the study period that contraindicates continued participation

Treatments and study arms

Resistance Training

Other

Progressive resistance training program including upper body (chest press), back (lat pulldown), abdominal (crunch), and lower body (squat) exercises. Performed 3 times per week for 8 weeks. Each session includes warm-up (10 min), main exercises (30 min), and cool-down (10 min). Intensity: 60-85% of 1RM, progressing weekly.

Electrical Muscle Stimulation

Device

Electrical muscle stimulation applied to biceps brachii, abdominals, back, and quadriceps muscles using a commercial EMS device. Parameters: frequency 35-70 Hz, pulse duration 100 μs, pulse period 50 ms, electrode size 150 × 240 mm. Performed 3 times per week for 8 weeks, 15 minutes per session. Intensity progressively increased based on participant tolerance.

No Intervention

Other

Participants in the control group receive no exercise intervention during the 8-week study period.

Primary outcomes

Change in Phase Angle (PhA) as a Cellular Health IndexMeasured at baseline (before intervention) and 48 hours after the last training session (week 8).

Phase angle (PhA) measured using bioelectrical impedance analysis (Inbody770). PhA is calculated as the ratio of reactance (Xc) to resistance (R) and serves as an indicator of cellular health, membrane integrity, and cell function.

Study locations

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Faculty of Sport Sciences, University of Birjand🌐 Birjand, South Khorasan Province, Iran

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