Clinical trial

Effect of GLP-1 Receptor Agonists on Periodontal Health and Response to Nonsurgical Periodontal Therapy

Opening soon · Not applicable · 0 countries · Registry ID NCT07770906

Opening soonNot applicableInterventional

What this study is about

This study aims to evaluate the effects of glucagon-like peptide-1 receptor agonist (GLP-1 RA) use on periodontal health and the response to non-surgical periodontal therapy in individuals with obesity and periodontitis. Participants with obesity and periodontitis will be divided into two groups: those who have been using a GLP-1 RA for at least 3 months and those who are not using any medication for obesity. All participants will receive the same non-surgical periodontal treatment, including oral hygiene instruction, scaling, and root planing. Periodontal clinical measurements and gingival crevicular fluid samples will be collected before treatment and at 3 and 6 months after treatment. The study will compare changes in periodontal health and inflammatory markers between the two groups to determine whether GLP-1 RA use is associated with periodontal health and the response to non-surgical periodontal therapy.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to Not listed

SexAll

Healthy volunteersNot accepted

ConditionPeriodontal Disease, Obesity & Overweight

Full registry criteria

Inclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥25 kg/m² * Presence of at least 20 functional teeth * Diagnosis of periodontitis * For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months Exclusion Criteria: * Age between 18 and 65 years * Body mass index (BMI) ≥25 kg/m² * Presence of at least 20 functional teeth * Diagnosis of periodontitis * For the GLP-1 receptor agonist group: regular use of a GLP-1 receptor agonist for at least 3 months

Treatments and study arms

non-surgical periodontal therapy

Procedure

All participants will receive oral hygiene instructions, including instruction in the modified Bass toothbrushing technique. Non-surgical periodontal therapy will be performed under local anesthesia in two sessions and will include full-mouth subgingival instrumentation and scaling and root planing using ultrasonic instruments and Gracey curettes. No adjunctive antimicrobial agents will be used.

Primary outcomes

Probing DepthBaseline, 3 months- 6 months

Study locations

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No public site location was included in this record. Check the original registry for updates.