Clinical trial

Impact of Antioxidant-rich Supplementation on Skin Carotenoids Status, Antioxidant Status and Cardiometabolic Health in Overweight and Obese Individuals

Opening soon · Not applicable · 1 countries · Registry ID NCT07748468

Opening soonNot applicableInterventional

What this study is about

This study aims to evaluate the effects of antioxidant-rich supplementation on skin carotenoid status, antioxidant status, and cardiometabolic health in overweight and obese individuals. The study may provide additional scientific evidence to support the further refinement of current dietary and nutritional recommendations.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age21 Years to 70 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight , Obesity, Antioxidant Status

Full registry criteria

Inclusion Criteria: * Able to give informed consent (AMT score ≥ 8 for older adults \[65-70 years old\]) * Adults 21-70 years old * English-literate * Have venous access sufficient to allow for blood sampling as per the protocol * No drastic change of diet for the past 1 year * If taking medication, has been consistently taking antihypertensive/cholesterol-lowering/type-2 diabetic medication for more than 3 years prior to starting the study Exclusion Criteria: * Weight change \> 3kg in the past 3 months * Exercising vigorously over the past 3 months * Taking medications or dietary supplements which may impact eye/skin health * Taking lipid-lowering and blood pressure controlling medications less than 3 years * Smoking * Drinking more than 2 alcoholic drinks per day * Pregnant, lactating, or planning pregnancy in the next 6 months

Treatments and study arms

Antioxidant-rich supplementation Element

Dietary Supplement

Maintained habitual diet with additionally taking LifePak Element for 12 weeks

Antioxidant-rich supplementation Optimal

Dietary Supplement

Maintaining habitual diet with additionally taking LifePak Optimal for 12 weeks

Primary outcomes

Change in Skin Carotenoid Score Measured by Prysm iO™ from Baseline to Week 12Week 0, 4, 8, 12

Skin carotenoid status will be assessed using the Prysm iO™ device. The device scans the participant's fingertip and provides a skin carotenoid score, also referred to as the Prysm Score. Results will be reported as the numerical Prysm Score. Higher scores indicate higher skin carotenoid levels.

Mean Change from Baseline in Blood Carotenoid ConcentrationWeek 0 and Week 12

Blood carotenoid concentration will be assessed using blood samples collected from participants. Results will be reported as the mean change from baseline in blood carotenoid concentration at Week 12. Higher concentrations indicate higher circulating carotenoid status.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

NUS, Department of Food Science and Technology, 1 Science Drive 3, Block S13, #03-07, Singapore, 117550🇸🇬 Singapore, Singapore

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Lingyin Yu, B.Sc.Contact

Email · Call (+65) 8942 1809

Jung Eun Kim, Ph.D., R.D.Principal Investigator