Clinical trial

Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery

Opening soon · Phase 4 · 1 countries · Registry ID NCT07748247

Opening soonPhase 4Interventional

What this study is about

This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to continuous desflurane anesthesia with respect to extubation time in adults undergoing elective laparoscopic bariatric surgery. Secondary outcomes include time to achieve a Patient State Index (PSi) greater than 80, time to achieve an Aldrete score of at least 8, incidence of postoperative nausea and vomiting, post-anesthesia care unit length of stay, and desflurane-related costs.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionObesity, Bariatric Surgery

Full registry criteria

Inclusion Criteria: * Age 18 years or older. * Scheduled for elective laparoscopic gastric bypass surgery. * Body mass index between 30 and 50 kg/m². * American Society of Anesthesiologists physical status II or III. * Able and willing to provide written informed consent. Exclusion Criteria: * Surgical procedure lasting less than 2 hours. * Body mass index greater than 50 kg/m². * Significant cardiac disease. * Moderate or severe obstructive respiratory disease, including uncontrolled asthma or chronic obstructive pulmonary disease. * Pregnancy or breastfeeding. * Known allergy or contraindication to medications used during the intraoperative period. * Personal or family history of malignant hyperthermia. * Active illicit drug use or substance dependence. * Advanced chronic kidney disease, defined as an estimated glomerular filtration rate below 60 mL/min. * Myasthenia gravis or another neuromuscular junction disorder. * Severe cognitive or psychiatric disorder. * Refusal to participate or withdrawal of informed consent at any time.

Treatments and study arms

Desflurane

Drug

Desflurane administered as the inhalational anesthetic throughout the surgical procedure.

Sevoflurane-Desflurane

Drug

Sevoflurane administered during the initial phase of surgery followed by desflurane beginning 30 minutes before surgical closure.

Primary outcomes

Extubation TimePerioperative

Time in seconds from discontinuation of inhaled anesthetic agents to removal of the endotracheal tube.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Clínica Dávila🇨🇱 Santiago, Santiago Metropolitan, Chile

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Alejandra Alejandra Rivera, MsC EpidemiologyContact

Email · Call 930363776