Clinical trial

Weight Loss and Hunger

Opening soon · Not applicable · 1 countries · Registry ID NCT07739095

Opening soonNot applicableInterventional

What this study is about

Weight loss is difficult and weight maintenance even worse. The principles of dieting dictate that to maintain weight loss, one has to eat less calories than they did before the diet. However, there is evidence to show that it may be the diet per se and not the weight loss that makes people more hungry and vulnerable to weight regain. This study will explore whether appetite control can be restored to normal levels through an individually tailored increase in calories after weight loss. If supported, the findings from this study could alter the way we view dieting.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 55 Years
SexAll
Healthy volunteersNot accepted
ConditionObesity & Overweight

Full registry criteria

Inclusion Criteria: 1. 18-55 years of age; 2. non-smoking; 3. obese class I-II (30 kg/m2 ≤ BMI \< 40 kg/m2); 4. weight stable (± 2 kg during the 6 months prior to enrollment); 5. Sedentary (\<2 times/week of 30 min of continuous exercise) In addition, Females will be included if: 1\) premenopausal (2 menses in the 3 months preceding testing, no increase in cycle irregularity in the 12 months preceding testing). Exclusion Criteria: 1. have a current diagnosis of an axis 1 psychiatric disorder (i.e. mood, anxiety and eating disorders); 2. currently use antidepressants, thyroid medication, or any medication that could affect appetite; 3. have a history of cardiac problems or symptoms suggestive of any cardiac condition; 4. have a current diagnosis or history of diabetes, confirmed by a measure of HbA1c during the screening visit; 5. have alcohol intake that exceeds recommendations or alcoholism, or current addictions to opiates, cocaine or stimulants; 6. currently taking monoamine oxidase inhibitors, pressor agents, warfarin, anticonvulsants, phenylbutazone, or tricyclic antidepressants; 7. have uncontrolled thyroid disease; 8. have any osteoarticular condition, or other reasons that would prevent them from achieving the proposed walking targets. In addition, Females will be excluded if they: 1. are pregnant or planning to become pregnant over the course of the study; 2. are peri- or post-menopausal or have had surgically induced menopause.

Treatments and study arms

Exercise

Behavioral

Daily kilometer target at normal walking pace (\~5km/h). The American College of Sports Medicine (ACSM) metabolic equation for the caloric cost of walking will be used to assess the distance needed to be covered daily.

Dietary Intervention

Behavioral

Participants will be prescribed a 20-week energy-restricted diet (-25% of energy requirements). A registered dietitian will be responsible for nutrition counselling and will use the Canadian Diabetes Association's Exchange System to prescribe the diet plan. During the weight loss phase, participants will receive a revised diet plan, based on the adjusted energy requirements that will account for the achieved weight loss. After weight loss, the diet plan will be revised based on the group (high-energy flux vs low-energy flux) to be in a state of energy balance.

Primary outcomes

Appetite measurementsBaseline (1 week before the dietary intervention), end of week 20 (after the weight-loss intervention), onset of week 25 (after the 1-month weight-maintenance period).

Desire to eat, hunger, fullness, and prospective food consumption (PFC) will be rated immediately before (after a 12 h overnight fast) and every 30 min\*3 h after the standardized breakfast on a 100-mm visual analog scale (VAS) adapted from Hill and Blundell. Scores range from 0 to 100 millimeters. For hunger, desire to eat, and prospective food consumption, higher scores indicate greater appetite. For fullness, higher scores indicate greater fullness (lower appetite). The satiety quotient will be calculated for each subject.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Ottawa🇨🇦 Ottawa, Ontario, Canada
Eric Doucet, PhDContact
Noemie Beauregard, PhD (c)Contact
Eric Doucet, PhDPrincipal Investigator