Clinical trial
Weight Loss and Hunger
Opening soon · Not applicable · 1 countries · Registry ID NCT07739095
What this study is about
Weight loss is difficult and weight maintenance even worse. The principles of dieting dictate that to maintain weight loss, one has to eat less calories than they did before the diet. However, there is evidence to show that it may be the diet per se and not the weight loss that makes people more hungry and vulnerable to weight regain. This study will explore whether appetite control can be restored to normal levels through an individually tailored increase in calories after weight loss. If supported, the findings from this study could alter the way we view dieting.
Basic eligibility
Full registry criteria
Treatments and study arms
Exercise
Daily kilometer target at normal walking pace (\~5km/h). The American College of Sports Medicine (ACSM) metabolic equation for the caloric cost of walking will be used to assess the distance needed to be covered daily.
Dietary Intervention
Participants will be prescribed a 20-week energy-restricted diet (-25% of energy requirements). A registered dietitian will be responsible for nutrition counselling and will use the Canadian Diabetes Association's Exchange System to prescribe the diet plan. During the weight loss phase, participants will receive a revised diet plan, based on the adjusted energy requirements that will account for the achieved weight loss. After weight loss, the diet plan will be revised based on the group (high-energy flux vs low-energy flux) to be in a state of energy balance.
Primary outcomes
Desire to eat, hunger, fullness, and prospective food consumption (PFC) will be rated immediately before (after a 12 h overnight fast) and every 30 min\*3 h after the standardized breakfast on a 100-mm visual analog scale (VAS) adapted from Hill and Blundell. Scores range from 0 to 100 millimeters. For hunger, desire to eat, and prospective food consumption, higher scores indicate greater appetite. For fullness, higher scores indicate greater fullness (lower appetite). The satiety quotient will be calculated for each subject.
Study locations
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