Clinical trial

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight

Recruiting now · Phase 1 · 2 countries · Registry ID NCT07738614

Recruiting nowPhase 1Interventional

What this study is about

The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 and 8 days. There will be 13 other visits.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years
SexAll
Healthy volunteersAccepted
ConditionObesity, Overweight

Full registry criteria

Inclusion Criteria: * Have overweight or obesity, but are otherwise overtly healthy. * Have a body mass index (BMI) within the range of 27.0 to 45.0 kilograms (kg)/square meter (m²), inclusive. * Have had a stable body weight, with less than 5 percent (%) change during the 3-month period prior to screening. Exclusion Criteria: * Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have either of the following at screening * A fasting plasma glucose concentration greater than or equal to 126 milligrams (mg)/deciliter (dL) or 7.0 millimoles (mmol)/liter (L), or * Hemoglobin A1C (HbA1c) greater than or equal to 6.5% or 48 mmol/mole (mol). * Have a history or presence of psychiatric disorders, including a history of major depressive disorder or severe psychiatric disorders such as schizophrenia, and bipolar disorder, within the last 2 years. * Have received a glucagon-like peptide-1 (GLP-1) receptor agonist, glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist, or GIP/GLP-1/glucagon receptor agonist within 60 days or 5 half-lives, whichever is longer, prior to screening. * Are in the judgment of the investigator, actively suicidal or deemed to be at significant risk for suicide.

Treatments and study arms

Eloralintide

Drug

Administered SC

Placebo

Drug

Administered SC

Acetaminophen

Drug

Administered Oral Solution

Primary outcomes

Acetaminophen Area Under the Concentration Versus Time Curve (AUC)Baseline to Day 65
Acetaminophen Maximum Observed Concentration (Cₘₐₓ)Baseline to Day 65
Acetaminophen Time to Maximum Observed Drug Concentration (tₘₐₓ)Baseline to Day 65

Study locations

2 locations were listed when this page was built. The first 40 are shown.

Lilly Centre for Clinical Pharmacology🇸🇬 Singapore, Singapore
Study contactContact
Greg LiPrincipal Investigator
ICON Early Phase Services🇺🇸 San Antonio, Texas, United States
Study contactContact
Chinonye Ogbonnaya-OdorPrincipal Investigator