Clinical trial

A Study to Learn How Different Amounts of the Study Medicine Called PF-08642534 Are Tolerated and Act in the Body of People Who Have Obesity

Opening soon · Phase 1 · 1 countries · Registry ID NCT07731139

Opening soonPhase 1Interventional

What this study is about

This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body). People who want to join the study will first go through a screening period of up to 4 weeks. Doctors will check if each person meets the study conditions, including age, body weight, and general health. People with certain medical conditions will not be able to take part in the study.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 70 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity

Full registry criteria

Inclusion: * Body mass index (BMI) ≥30.0 and ≤40.0 kg/m², and with stable body weight prior to screening. * Participants are generally otherwise healthy but may have mild chronic conditions (eg, dyslipidemia or hypertension) Exclusion: \- Individuals with diabetes, significant cardiovascular, hepatic, renal, gastrointestinal, or psychiatric disorders, or conditions that may affect drug absorption or metabolism, are not eligible to participate.

Treatments and study arms

PF-08642534

Drug

Participants will receive PF-08642534 QD (once a day)

Placebo

Drug

Participants will receive matching placebo QD (once a day)

Primary outcomes

Incidence of treatment emergent adverse events (TEAE)Baseline up to 8 weeks after last dose

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Orange County Research Center🇺🇸 Lake Forest, California, United States

Open map