Clinical trial

Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07730255

Active, not recruitingNot applicableInterventional

What this study is about

This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic profile, and metabolomic profile in older women with obesity. Forty women aged 60 to 75 years with obesity will be randomized into four groups: control, exercise, taurine, and exercise plus taurine. The intervention will last 16 weeks. Outcomes include magnetic resonance imaging, body composition, muscle biopsy, blood biomarkers, functional capacity tests, transcriptomic analysis, and metabolomic analysis.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age60 Years to 75 Years

SexFemale

Healthy volunteersNot accepted

ConditionObesity (BMI>30)

Full registry criteria

Inclusion Criteria: * Female, * 60 and 75 years of age, * Body mass lower than 120 kg, * Be sedentary (not having engaged in physical exercise for at least 3 months), and * Body Mass Index between 30 and 40 kg/m². Exclusion Criteria: * alcohol consumption, * smoking, * infectious and contagious diseases, * chronic kidney diseases, * undergoing weight loss treatment, and * presenting a score ≤13 on cognitive screening using the Mini-Mental State Examination (MMSE).

Treatments and study arms

Concurrent Exercise Training

Behavioral

Participants will perform supervised concurrent exercise training three times per week for 16 weeks. Exercise sessions will include warm-up, resistance exercises, aerobic training, and stretching exercises, according to American College of Sports Medicine (ACSM) recommendations for older adults.

Taurine

Dietary Supplement

Participants will receive 3 grams per day taurine supplementation administered orally in capsules for 16 weeks.

Placebo

Other

Participants will receive placebo capsules identical in appearance to taurine capsules.

Primary outcomes

Change from Baseline in Intramuscular Fat Fraction Assessed by Magnetic Resonance Imaging (Dixon Technique)Baseline and 16 weeks

Intramuscular fat fraction assessed by magnetic resonance imaging (MRI) using the Dixon technique, reported as percentage (%) of fat within the muscle tissue. Change is calculated from baseline to Week 16.

Change from baseline in skeletal muscle transcriptomic profileBaseline and 16 weeks

Skeletal muscle biopsy samples will be analyzed using RNA sequencing to characterize changes in the skeletal muscle transcriptomic profile following the intervention.

Change from baseline in plasma metabolomic profile16 weeks

Plasma samples will be analyzed using untargeted metabolomic analysis to evaluate changes in the plasma metabolomic profile after 16 weeks of intervention.

Change from baseline in plasma taurine concentrationBaseline and 16 weeks

Plasma taurine concentration will be measured before and after the 16-week intervention.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Escola de Educação Física e Esporte de Ribeirão Preto, Ribeirão Preto, São Paulo.🇧🇷 Ribeirão Preto, São Paulo, Brazil

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