Clinical trial
AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
Opening soon · Phase 3 · 1 countries · Registry ID NCT07720271
Opening soonPhase 3Interventional
What this study is about
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionOverweight, Obesity
Full registry criteria
Inclusion Criteria: * Male or female (sex at birth). * Age 18 and older (both inclusive) at time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
Treatments and study arms
zenagamtide
Drug
zenagamtide will be taken orally.
Placebo
Drug
Placebo matched to zenagamtide will be taken orally.
Primary outcomes
Relative change in body weightFrom baseline (week 0) to (week 76)
Measured as percentage (%) change in body weight.
Study locations
37 locations were listed when this page was built. The first 40 are shown.
Amarillo Medical Specialists🇺🇸 Amarillo, Texas, United States
Pinnacle Research Group LLC🇺🇸 Anniston, Alabama, United States
Washington Cntr Weight Mgmt🇺🇸 Arlington, Virginia, United States
Univ of Colorado at Denver🇺🇸 Aurora, Colorado, United States
Univ of Alabama Birmingham🇺🇸 Birmingham, Alabama, United States
Northern Pines Hlth Ctr, PC🇺🇸 Buckley, Michigan, United States
Medical Uni of SC Charleston🇺🇸 Charleston, South Carolina, United States
Great Lakes Clinical Trials🇺🇸 Chicago, Illinois, United States
StudyMetrix Research LLC🇺🇸 City of Saint Peters, Missouri, United States
Hope Clin Res & Wellness🇺🇸 Conyers, Georgia, United States
Clinical Res Collaborative🇺🇸 Cumberland, Rhode Island, United States
North Texas Endocrine Center🇺🇸 Dallas, Texas, United States
ERG Holding Company, LLC / Evolution Research Group, LLC🇺🇸 Delray Beach, Florida, United States
Northeast Research Institute🇺🇸 Fleming Island, Florida, United States
Providence Medical Foundation🇺🇸 Fullerton, California, United States
Clinical Investigation Spec Gurnee🇺🇸 Gurnee, Illinois, United States
Miguel Rebollar PA🇺🇸 Hialeah, Florida, United States
East West Medical Research Institute_Honolulu🇺🇸 Honolulu, Hawaii, United States
Midwest Inst For Clin Res🇺🇸 Indianapolis, Indiana, United States
Jacksonville Ctr Clin Res🇺🇸 Jacksonville, Florida, United States
Palm Research Center Inc.🇺🇸 Las Vegas, Nevada, United States
Torrance Clinical Research Institute, Inc.🇺🇸 Lomita, California, United States
South Broward Research LLC🇺🇸 Miramar, Florida, United States
Chambliss Clinical Trials LLC🇺🇸 Montgomery, Alabama, United States
Comprehensive Weight Ctrl Prog🇺🇸 New York, New York, United States
Health Res of Hampton Roads🇺🇸 Newport News, Virginia, United States
Lynn Institute of Norman🇺🇸 Norman, Oklahoma, United States
Coastal Carolina Research Ctr🇺🇸 North Charleston, South Carolina, United States
Clinical Neuroscience Solution🇺🇸 Orlando, Florida, United States
Florida Institute for Clinical Research, LLC🇺🇸 Orlando, Florida, United States
Oviedo Medical Research, LLC🇺🇸 Oviedo, Florida, United States
National Clin Res Inc.🇺🇸 Richmond, Virginia, United States
Hillcrest Clinical Research🇺🇸 Simpsonville, South Carolina, United States
Endeavor Health🇺🇸 Skokie, Illinois, United States
Evanston Premier Hlthcr Res🇺🇸 Skokie, Illinois, United States
Spartanburg Medical Research🇺🇸 Spartanburg, South Carolina, United States
Diablo Clinical Research, Inc.🇺🇸 Walnut Creek, California, United States