Clinical trial

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

Opening soon · Not applicable · 0 countries · Registry ID NCT07711548

Opening soonNot applicableInterventional

What this study is about

So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy. This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 70 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity & Overweight, Weight Loss Maintenance

Full registry criteria

Inclusion Criteria: * BMI ≥ 30 kg/m² OR ≥ 27 kg/m² with concomitant cardiometabolic risk factors (metabolic syndrome, elevated blood pressure, dyslipidemia or impaired glucose metabolism (but not type 2 diabetes) Exclusion Criteria: * BMI ≥ 45 kg/m² * intake of glucose lowering drugs * presence of incretin-based treatment * acute severe CVD * uncontrolled hypertension * severe hepatic or renal diseases * severe food allergy or malabsorption disease * active cancer * condition after bariatric surgery * history of eating disorder * concurrent pregnancy and breastfeeding

Treatments and study arms

NutriAct plus

Behavioral

Dietary pattern, vegetarian version of the NutriAct pattern

Rescue VLCD

Behavioral

Very low calorie diet as full meal replacement over 28 days in case of weight regain

Primary outcomes

weight in kgbody weight in kg after weight loss (3 to 5 months) and dietary intervention (12 months)

Study locations

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No public site location was included in this record. Check the original registry for updates.