Clinical trial

A Research Study on How UBT251 Affects Levels of Midazolam, Caffeine and Warfarin in the Blood of Participants With Excess Body Weight

Recruiting now · Phase 1 · 1 countries · Registry ID NCT07710768

Recruiting nowPhase 1Interventional

What this study is about

The purpose of this clinical study is to find out if UBT251 is safe and effective to be taken together with medicines, like midazolam, caffeine and warfarin in participants living with overweight or obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years
SexAll
Healthy volunteersAccepted
ConditionObesity, Overweight

Full registry criteria

Inclusion Criteria: * Male or female (sex assigned at birth, inclusive of all gender identities). * Age 18-65 years (both inclusive) at the time of signing the informed consent. * BMI between 27.0-39.9 kg/m\^2 (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator. * Body weight \>=60.0 kg. * Considered to be generally healthy, except for overweight or obesity, based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) or related products. * Treatment with any marketed product containing compounds with glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), or glucagon (GCG) receptor agonism within 90 days before screening. * Use of prescription medicinal products or non-prescription drugs, including any herbal medicine known to interfere with the metabolic CYP pathways, such as perikon (St. John's Wort), ginseng, garlic, milk thistle, and echinaceae, within 14 days (or within 5 half-lives of the medicinal product, whichever is longest) of screening, with the exception of use of routine vitamins (vitamins used within a normal dose reference interval), occasional use of acetaminophen, ibuprofen, or topical medication not reaching systemic circulation. * Any contraindications for the use of caffeine, midazolam, and warfarin used in the study according to Vivarin®, Midazolam®, and warfarin sodium product information. * Presence of clinically significant gastrointestinal disorders or symptoms of gastrointestinal disorders potentially affecting absorption of drugs or nutrients, or as judged by the investigator. * History of major surgical procedures involving the stomach potentially affecting absorption of trial products (e.g. subtotal and total gastrectomy, sleeve gastrectomy, gastric bypass surgery) or current presence of gastrointestinal implant.

Treatments and study arms

UBT251

Drug

Administered subcutaneously.

Cocktail (Warfarin/Caffeine/Midazolam)

Drug

Administered orally.

Primary outcomes

AUC0-∞,s-warfarin: The area under the plasma s-warfarin concentration-time curve extrapolated to infinity after single doseFrom pre-dose on Day 1 up to 156 days

Measured in nanogram hour per millilitre (ng\*h/mL).

AUC0-∞,caffeine : The area under the plasma caffeine concentration-time curve extrapolated to infinity after single doseFrom pre-dose on Day 1 up to 156 days

Measured in ng\*h/mL.

AUC0-∞,midazolam: The area under the midazolam concentration-time curve extrapolated to infinity after single doseFrom pre-dose on Day 1 up to 156 days

Measured in ng\*h/mL.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Altasciences Clinical LA, Inc.🇺🇸 Cypress, California, United States