Clinical trial

The Effect of Fasting on Peak Fat Oxidation, Mitochondrial Coupling and Extracellular Matrix

Recruiting now · Not applicable · 1 countries · Registry ID NCT07692646

Recruiting nowNot applicableInterventional

What this study is about

The interventional study will recruit four groups (n=10 per group): Young men and women with normal weight (BMI 18-25), and young men and women with obesity (BMI \>30). The study will investigate the effect of 84 hours of fasting on peak fat oxidation, mitochondrial coupling and the extracellular matrix.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 40 Years

SexAll

Healthy volunteersAccepted

ConditionFasting, Obesity (BMI>30), Sex Difference

Full registry criteria

Inclusion Criteria: * Healthy normal weight men aged \[18,40\] and BMI \[18,25\] * Healthy normal weight women \[18,40\] and BMI \[18,25\] * Healthy obese men \[18,40\] and BMI \[30,40\] * Healthy obese women \[18,40\] and BMI \[30,40\] Exclusion Criteria: * Present or former cardiovascular disease and chronical inflammatory disease * Consumption of medications and supplements that influence substrate use at rest and/or during exercise * Pregnancy

Treatments and study arms

Diet

Other

Long-term fasting (84 hours), physiological testing before and after fasting: sampling of blood, abdominal adipose tissue and skeletal muscle for molecular analysis and respiratory measurements at rest.

Primary outcomes

The effect of fasting and obesity on protein glycosylation of the extracellular matrix in adipose tissueThe fasting will last approximately 84 hours.

The composition and protein glycosylation of the extracellular matrix will be measured in abdominal subcutaneous adipose tissue samples in 20 healthy normal weight men and women and 20 healthy obese men and women.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Department of Biomedical Sciences🇩🇰 Copenhagen, Denmark

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Jørn W Helge, PhDContact

Email · Call +4528757506