Clinical trial
Effects of GLP-1RAs on Fertility Outcomes in Obese Women With PCOS
Opening soon · Not applicable · 1 countries · Registry ID NCT07687667
Opening soonNot applicableInterventional
What this study is about
The goal of this clinical trial is to examine whether GLP1-RA and healthy lifestyle education in women with PCOS and obesity prior to fertility treatment improves live birth rate and other reproductive, maternal and perinatal outcomes compared to metformin plus healthy lifestyle education.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 40 Years
SexFemale
Healthy volunteersNot accepted
ConditionPolycystic Ovary Syndrome (PCOS), Obesity, Infertility, Female
Full registry criteria
Inclusion Criteria: * Women with a wish to conceive; * Women with PCOS (Rotterdam criteria); * 28 kg/m2≤BMI\<35kg/m2; * Age: 18-40 years old Exclusion Criteria: * Women with diseases unsuitable for pregnancy or any other contraindications to infertility treatment Endocrine disorders; Abnormalities in liver and kidney function; Other medications such as glucocorticoids, anti-androgen drugs ;(spironolactone, cyproterone acetate, flutamide, etc.) within the last 3 months; Acute infections, severe cardiovascular disease, malignant tumors; Ongoing weight loss therapy (\>5% weight loss in the last 3 months) or history of gastrointestinal surgery; Uterine abnormalities that may affect assisted reproductive outcomes, untreated hydrosalpinx Male azoospermia, severe oligozoospermia and asthenospermia, or patients receiving donor sperm treatment Chromosomal abnormalities, patients planning preimplantation genetic testing (PGT) or donor oocyte treatment History of recurrent miscarriag Allergic to or contraindicated for GLP-1 class medications.
Treatments and study arms
GLP-1 receptor agonist
Drug
12 weeks treatment
Metformin
Drug
12 weeks treatment
Primary outcomes
Ongoing Pregnancy RateFirst cycle of IVF/ICSI-ET (the first frozen-thawed embryo transfer cycle if all embryos are cryopreserved after oocyte retrieval)
Ongoing Pregnancy Rate (OPR) The percentage of embryo transfer cycles with an intrauterine pregnancy sustained beyond 20 gestational weeks, with a gestational sac and fetal cardiac activity confirmed via transvaginal ultrasound, out of all embryo transfer cycles.
Study locations
1 locations were listed when this page was built. The first 40 are shown.
Peking University Third Hospital🇨🇳 Beijing, Beijing Municipality, China
Liang LiangContact