Clinical trial

Weight Loss Composition and Metabolic Adaptation During Hypocaloric Dieting

Opening soon · Not applicable · 0 countries · Registry ID NCT07627256

Opening soonNot applicableInterventional

What this study is about

Weight loss induced by hypocaloric dietary interventions is commonly accompanied by reductions in resting metabolic rate (RMR), a phenomenon often described as metabolic adaptation. The magnitude of this decline varies substantially between individuals and may depend not only on the amount of weight lost but also on the composition of weight loss, particularly the relative contributions of fat mass and fat-free mass. This prospective interventional study will investigate whether changes in body composition during a hypocaloric dietary intervention are associated with changes in RMR and metabolic adaptation. Approximately 150 adults with overweight or obesity will participate in a structured dietary program designed to induce moderate energy restriction. Body composition and resting metabolic rate will be assessed before and after the intervention to evaluate associations between fat mass loss, fat-free mass loss, and metabolic responses to weight reduction.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionObesity

Full registry criteria

Inclusion Criteria * Adults aged 18 years and older. * Individuals living with overweight or obesity. * Willingness and ability to comply with dietary recommendations and study procedures. * Provision of written informed consent. Exclusion Criteria * Diagnosed metabolic or endocrine disorders known to affect energy expenditure. * Use of medications known to substantially affect metabolism or body composition. * Pregnancy or breastfeeding. * Any medical condition that, in the opinion of the investigators, precludes safe participation.

Treatments and study arms

Hypocaloric Diet

Behavioral

Participants will follow individualized dietary plans designed to produce an energy deficit of approximately 500-600 kcal/day relative to measured resting metabolic rate. Protein intake will be prescribed at approximately 1.5 g/kg body weight per day to support preservation of fat-free mass. Dietary plans will be adjusted as needed during the intervention period, and participants will attend regular follow-up visits to monitor progress and adherence.

Primary outcomes

Change in Resting Metabolic RateBaseline to end of dietary intervention (up to 12 months)

Change in resting metabolic rate (RMR) measured by indirect calorimetry between baseline and post-intervention assessment.

Study locations

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No public site location was included in this record. Check the original registry for updates.