Clinical trial

Long-term Health and Economic Effects of an Individualized Lifestyle Intervention (LI-PAD-Extended)

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07605169

Active, not recruitingNot applicableInterventional

What this study is about

The goal of this clinical trial is to learn if an individualized lifestyle intervention works to improve weight, diet, physical activity, cardiovascular health, health-related quality of life, and cost-effectiveness in overweight and obese adults aged 45-65 years. The main questions it aims to answer are: Does the intervention lead to sustained weight loss after 18 months? Does the intervention improve cardiovascular risk factors, metabolic markers, and health-related quality of life compared to general written advice? Is the intervention cost-effective? Researchers will compare the individualized lifestyle intervention to a control group that receives general written advice on physical activity and diet to see if the intervention provides greater long-term health and economic benefits. Participants will: Attend counseling sessions with a health promoter Take part in supervised aerobic and resistance training with a physiotherapist Use swimming facilities and participate in the Lifestyle School Access a digital health coach and the online Lifestyle Tool Complete measurements of body weight, diet, physical activity, and cardiovascular health markers (waist-to-hip ratio, blood pressure, blood lipids, fasting glucose, HbA1c, CRP, and liver enzymes) Complete assessments of resting energy expenditure, aerobic fitness, muscle strength, motivation, and health-related quality of life Provide blood samples at baseline, 6 months, and 18 months for dietary biomarker analysis Contribute data for health economic evaluation to assess cost-effectiveness

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age45 Years to 65 Years

SexAll

Healthy volunteersNot accepted

ConditionOverweight, Obesity, Prediabetic State

Full registry criteria

Inclusion Criteria: * Adults aged 45-65 years at baseline of the original LI-PAD study * Body mass index (BMI) ≥28 and ≤34 * Completed the original LI-PAD study * Able and willing to attend follow-up assessments and provide necessary data * Able and willing to provide informed consent Exclusion Criteria: * Known coronary artery disease (clinical symptoms or earlier event) * Inability to understand the language used in the study * Inability to complete follow-up assessments at 18 months * Severe illness or medical condition that, in the investigator's opinion, precludes participation in follow-up assessments

Treatments and study arms

Individualized physical activity and diet

Behavioral

Precision health

Primary outcomes

Body Weight ChangeBaseline, 6 months, 18 months

Change from baseline in body weight measured using calibrated scales and standardized protocols.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Centre for Lifestyle Intervention🇸🇪 Gothenburg, Västra Götaland County, Sweden

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