Clinical trial

Genetic Markers Associated With Capsaicinoid Supplementation Effects in Overweight and Obesity

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07602361

Active, not recruitingNot applicableInterventional

What this study is about

Capsaicinoids, compounds found in chili peppers of the genus Capsicum, are responsible for their spiciness and may have potential benefits in weight control and cardiometabolic health. They act on processes such as appetite regulation, fat burning, inflammation, and metabolism, although their effects vary among individuals, possibly due to genetic factors. In Mexico, where chili consumption is high and obesity is a significant public health problem, it is particularly relevant to study these genetic variations. The proposed research aims to identify genetic markers that can predict the response to capsaicinoid supplementation and thus develop personalized nutritional strategies for the treatment of obesity and its complications.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age25 Years to 60 Years

SexAll

Healthy volunteersNot accepted

ConditionOverweight and Obesity

Full registry criteria

Inclusion Criteria: * Adults diagnosed with overweight or obesity within the age range established for the study * Willingness to participate in the study * Signed informed consent form Exclusion Criteria: * History of thyroid or metabolic disorders requiring pharmacological treatment, such as diabetes mellitus or coronary heart disease * Pregnant or breastfeeding women * Active smokers * High alcohol consumption, defined as \>20 g/day in women and \>40 g/day in men * Use of hypocaloric diets or weight-loss medications within the three months prior to study initiation * Daily chili consumption or high habitual intake of capsaicinoids * Known hypersensitivity to capsaicinoids * Gastrointestinal disorders, such as ulcerative colitis or irritable bowel syndrome

Treatments and study arms

Capsipro supplementation

Dietary Supplement

This intervention differs from similar studies due to the use of standardized capsaicin in fixed-dose capsules, rather than chili extracts, whole foods, or non-standardized mixtures. It is also distinguished by a continuous daily administration regimen over 16 weeks, which allows the assessment of sustained effects over time on anthropometric and metabolic parameters under controlled conditions.

Corn starch placebo

Dietary Supplement

Capsules indistinguishable from Capsipro, composed of corn starch, administered twice daily for 16 weeks

Primary outcomes

Change in body fat percentageBaseline to 16 weeks

Body fat percentage will be assessed using standardized body composition analysis methods to evaluate changes following capsaicinoid supplementation.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Universidad Autónoma de Baja California🇲🇽 Tijuana, Estado de Baja California, Mexico

Open map