Clinical trial
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
Recruiting now · Phase 2 · 2 countries · Registry ID NCT07575932
Recruiting nowPhase 2Interventional
What this study is about
This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionOverweight, Obesity, Overweight and/or Obesity, Overweight or Obesity, Overnutrition, Nutrition Disorders, Nutritional and Metabolic Diseases, Body Weight
Full registry criteria
Inclusion Criteria: Eligible participants for this study include: * adults aged 18 years or older with * obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with * overweight (BMI of 27.0 kg/m2 to \<30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit. Exclusion Criteria: Participants who are not eligible include those with diabetes mellitus, a body weight change of \>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.
Treatments and study arms
PF-08653945
Drug
Subcutaneous Injection
PF-08653944
Drug
Subcutaneous Injection
Placebo
Drug
Subcutaneous Injection
Primary outcomes
Percent change from baseline in body weightBaseline (Week 0) to Week 48
Study locations
65 locations were listed when this page was built. The first 40 are shown.
Aggarwal and Associates Limited🇨🇦 Brampton, Ontario, Canada
Viable Clinical Research Corporation🇨🇦 Bridgewater, Nova Scotia, Canada
Ecogene-21🇨🇦 Chicoutimi, Quebec, Canada
Centricity Research Etobicoke Endocrinology🇨🇦 Etobicoke, Ontario, Canada
Milestone Research Inc.🇨🇦 London, Ontario, Canada
Centricity Research Mirabel Multispecialty🇨🇦 Mirabel, Quebec, Canada
Recherche GCP Research🇨🇦 Montreal, Quebec, Canada
Bluewater Clinical Research Group Inc.🇨🇦 Sarnia, Ontario, Canada
Centricity Research Toronto Manna Multispecialty🇨🇦 Toronto, Ontario, Canada
Dr. Anil K. Gupta Medicine Professional Corporation🇨🇦 Toronto, Ontario, Canada
Washington Center for Weight Management and Research🇺🇸 Arlington, Virginia, United States
Atlanta Diabetes Associates🇺🇸 Atlanta, Georgia, United States
Mercury Street Medical Group, PLLC🇺🇸 Butte, Montana, United States
San Fernando Valley Health Institute🇺🇸 Canoga Park, California, United States
Arizona Clinical Trials-Chandler🇺🇸 Chandler, Arizona, United States
DelRicht Research🇺🇸 Charlotte, North Carolina, United States
Tekton Research, LLC.🇺🇸 Edmond, Oklahoma, United States
Cedar Health Research - Euless🇺🇸 Euless, Texas, United States
Ark Clinical Research🇺🇸 Fountain Valley, California, United States
Paragon Rx Clinical🇺🇸 Garden Grove, California, United States
Bioluminux Clinical Research🇺🇸 Hamilton, New Jersey, United States
DelRicht Research🇺🇸 Hendersonville, Tennessee, United States
AGA Clinical Trials🇺🇸 Hialeah, Florida, United States
JCCT-JUNO NW Houston🇺🇸 Houston, Texas, United States
Westside Center for Clinical Research🇺🇸 Jacksonville, Florida, United States
Activian Clinical Research🇺🇸 Kingwood, Texas, United States
AB Clinical Trials🇺🇸 Las Vegas, Nevada, United States
Alliance Clinical Research Las Vegas (Excel Clinical Research)🇺🇸 Las Vegas, Nevada, United States
Palm Research Center🇺🇸 Las Vegas, Nevada, United States
Johnson County Clinical Trials🇺🇸 Lenexa, Kansas, United States
Torrance Clinical Research Institute, Inc.🇺🇸 Lomita, California, United States
Ark Clinical Research🇺🇸 Long Beach, California, United States
Collaborative Neuroscience Research, LLC🇺🇸 Los Alamitos, California, United States
Patient First Clinical Trials (PFCTRIALS)🇺🇸 Lutherville, Maryland, United States
Manassas Clinical Research Center🇺🇸 Manassas, Virginia, United States
DelRicht Research🇺🇸 Mandeville, Louisiana, United States
New Horizon Research Center🇺🇸 Miami, Florida, United States
Paradigm Clinical Research-Modesto🇺🇸 Modesto, California, United States
Monroe Biomedical Research🇺🇸 Monroe, North Carolina, United States
Koch Family Medicine Clinical Research/Elite Research Network🇺🇸 Morton, Illinois, United States