Clinical trial

Can Pre-operative Lean Mass Predict Weight Loss After Roux-en-Y Gastric Bypass?

Recruiting now · Not applicable · 1 countries · Registry ID NCT07565051

Recruiting nowNot applicableObservational

What this study is about

The goal of this observational study is to evaluate whether preoperative fat-free mass predicts post-operative weight loss in patients undergoing Roux-En-Y gastric bypass. The primary objective of this study is to evaluate whether preoperative fat-free mass predicts weight loss in the two years following RYGB. The investigators will collect the following data, assessed as part of routine follow-up: * height, weight, hip and waist circumferences * body composition by bioimpedance analysis and dual energy-X-ray absorptiometry * Muscle strength and physical activity * Nutritional parameters: resting energy expenditure, eating behavior and digestive tolerance", plasma micronutrient status. . * Cardiovascular risk factors: fasting glucose, blood levels of Hb1Ac, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, blood pressure * Co-morbidities: joint pain and arthritis, sleep apnea, gastro-oesophageal reflux, metabolic dysfunction-associated fatty liver disease (MAFLD), cancer, stroke, heart attack. Quality of life: quality of life by the "Bariatric Analysis and Reporting Outcome (BAROS) questionnaire", symptoms of dumping syndrome by the "Sigstad diagnostic score system" Birthdate, birthweight and term of their children

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

AgeNot listed to Not listed

SexAll

Healthy volunteersNot accepted

ConditionMorbid Obesity Requiring Bariatric Surgery

Full registry criteria

Inclusion Criteria: * Patients ≥ 18 years AND * Meeting inclusion criteria for RYGB (www.smob.ch): BMI ≥35 kg/m2, failure of weight-reducing programs over 2 years (for patients with a BMI ≥50 kg/m2, 1 year), understanding of the necessity to change the lifestyle and eating habits post-operatively, signed consent for lifelong post-operative follow-up in a recognized bariatric center AND * Scheduled RYGB at the HUG OR previous RYGB at the HUG with a present follow-up in Clinical Nutrition and dietetics at the HUG AND * Understanding French Exclusion Criteria: * Inability or refusal to give consent. * Planification for another type of bariatric surgery than RYGB * Contra-indications to bariatric surgery as stated under www.smob.ch: insufficient nutritional knowledge in nutrition to lose weight, pregnancy, kidney failure (Creatinine ≥ 300 umol/l without dialysis, Crohn's disease, active cancer or remission \< 2 years, active psychiatric disease, substance abuse (alcohol, cannabis, opioids), absence of compliance, lack of understanding of the requirements and necessary lifestyle changes reported by physician or dietician.

Treatments and study arms

The registry does not list a named intervention.

Primary outcomes

Correlation between Fat-free mass (FFM) and weight loss following RYGB2 years

FFM and lean body mass measurement using BIA and DXA, respectively

Evolution of body composition in the two years after bariatric surgery5 years

Measurments of body composition by dual energy X-ray absorptiometry before gastric bypass and yearly after gastric bypass

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Geneva University Hospitals🇨🇭 Geneva, Canton of Geneva, Switzerland

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