Clinical trial

Weight Loss and Endocrine Disrupting Chemicals (EDCs): Lifestyle Interventions to Lose Weight and Reduce EDC Exposure in Individuals With Overweight/Obesity

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07560579

Active, not recruitingNot applicableInterventional

What this study is about

The goal of this study is to examine the relationship in individuals with overweight/obesity and endocrine disrupting chemical (EDC) exposure through a two-armed, randomized clinical trial. The main questions this study aims to answer are: 1. If MM's 12-week EDC intervention program (EDC testing and report-back, EDC reduction curriculum) can reduce weight? 2. If a 12-week validated digital weight loss program can reduce EDC exposures? 3. What is the effectiveness of the two interventions at reducing weight and urinary EDC metabolites? Participants will be assigned to one of these two arms. Participants will collect their urine and blood samples pre- and post-intervention, and will take a comprehensive exposure survey before sending back their samples. This exposure survey will ask about participant's weight loss literacy, environmental health literacy, product use, diet, and lifestyle behaviors.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersNot accepted

ConditionObesity &Amp;Amp;Amp; Overweight, Environmental Exposure, Overweight (BMI > 25)

Full registry criteria

Inclusion Criteria: * BMI over 25 * Not pregnant or breast feeding * Do not have diabetes, kidney disease, liver disease, cardiac disease, pulmonary disease or cancer. * Do not smoke * Not in another weight loss program or on GLP-1 * Have access to a smartphone or computer Exclusion Criteria: * BMI under 25 * Pregnant or breast feeding * Have diabetes, kidney disease, liver disease, cardiac disease, pulmonary disease or cancer. * Smoke * In another weight loss program or on GLP-1 * Do not have access to a smartphone or computer

Treatments and study arms

Educational curriculum

Behavioral

A self-directed online interactive curriculum of EDC material, with access to live coaches and an online forum.

Weight loss Application

Behavioral

A paid, self-directed weight loss application.

Urinary EDC metabolite testing

Diagnostic Test

Mail-in urine samples tested for metabolites of bisphenols, phthalates, parabens, and oxybenzone.

Siphox clinic biomarker test

Diagnostic Test

Mail-in blood samples tested for clinical biomarkers.

Weight loss reporting

Diagnostic Test

Self-reported weight loss.

Primary outcomes

Changes in weight after intervention.Pre and post intervention (4 months between measurements)

EDC intervention that reduces EDC exposure also help individuals to lose weight. Comparing the two interventions to see which is more effective (EDC intervention or traditional weight loss intervention).

Changes in Endocrine Disrupting Chemical - Environmental Health Literacy (EDC-EHL) after the intervention.Measured before the intervention, after the intervention (4 months after baseline), and at follow-up (1 months after the intervention)

This surveys assesses EDC-specific environmental health literacy, based on questions in a 5-point Likert scale from 1 (strongly agree) to 5 (strongly disagree) or 1 (never) to 5 (always). Responses will be reverse coded during analysis as needed so that higher numbers reflect positive outcomes (higher EDC-EHL).

Changes in EDC metabolites after the interventionPre and post intervention (4 months in between measurements)

Urinary EDC metabolites include bisphenols, phthalates, parabens and oxybenzone

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Million Marker🇺🇸 Berkeley, California, United States

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