Opening soonNot applicableInterventional
What this study is about
This randomized controlled trial investigates the effects of two types of stair-climbing exercise snacks versus moderate-intensity continuous training on vascular health, body composition, and blood lipids in overweight or obese adults. Participants will be assigned to one of four groups for 6-8 weeks. The control group receives no exercise intervention. Primary outcomes include endothelial function (ultrasound), body composition (InBody), and lipid profile (blood test).
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to 35 Years
SexAll
Healthy volunteersNot accepted
ConditionOverweight, Obesity
Full registry criteria
Inclusion Criteria: 1. Age: 18-35 years old (male, female); 2. Clear consciousness, stable vital signs; 3. Able to understand and follow simple instructions; 4. No regular exercise for at least 3 months; 5. BMI ≥ 24 kg/m2. Exclusion Criteria: 1. There are other serious diseases, such as tumors; 2. There are other neurological diseases; 3. There are serious diseases that simultaneously affect the heart, liver, kidneys, endocrine system or hematopoietic system; 4. There is a history of alcohol or drug abuse; 5. Participated in other clinical trials that might affect the results of this study; 6. There are other neurological or musculoskeletal diseases, with pain worsening with exercise; 7. It is forbidden to engage in physical training. 8. Within the past 3 months, there have been acute cardiovascular events such as acute myocardial infarction,unstable angina pectoris, severe arrhythmia, acute heart failure, etc.； 9. Uncontrolled hypertension； 10. Severe pulmonary diseases, such as uncontrolled asthma, acute exacerbation of chronic obstructive pulmonary disease, interstitial lung disease with significant exercise limitation； 11. Severe joint and bone diseases, acute soft tissue injuries, fractures that have not healed, etc., making it impossible to complete the prescribed exercise load； 12. Presence of bleeding tendencies, coagulation dysfunction, or within the past 1 month, there has been major bleeding or a history of surgery； 13. The investigator judges that there are any other situations that may affect the safety of the subjects or the results of the trial.
Treatments and study arms
Short-term stair climbing exercise snack group
Behavioral
Adopt a fragmented approach, climbing stairs 4-5 times a day, each time climbing 5 floors (approximately 1 minute per session), with at least 1 hour of interval between each session, and spread throughout the daily activity periods. Exercise 3-5 days per week for a total of 6-8 weeks.
Long-duration stair climbing exercise snack group
Behavioral
On the basis of climbing stairs 4 to 5 times a day, increase the single exercise volume: complete 2 or 3 sets of climbing 5 floors of stairs each time (that is, the total number of floors climbed each time is 10 or 15), with no more than 1 minute of rest between sets. The intervals between each exercise should be at least 1 hour. Exercise 3 to 5 days a week, for a total of 6 to 8 weeks of intervention.
Moderate-intensity continuous exercise（MICT）
Behavioral
Exercise 3 to 5 days per week for a total of 6 to 8 weeks. Perform 30 minutes of moderate-intensity running training every day.
Primary outcomes
Flow-mediated dilation (FMD, relative percentage)Measured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Flow-mediated dilation expressed as a percentage of the baseline brachial artery diameter.Unit of Measure: %
Body fat massMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Body fat mass measured by bioelectrical impedance analysis (InBody device). Unit of Measure: kg
Time to peak dilationMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Time required to reach maximal dilation after cuff deflation.Unit of Measure: seconds
Basal brachial artery diameterMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Baseline diameter of the brachial artery before cuff inflation.Unit of Measure: mm
Peak brachial artery diameterMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Maximal diameter of the brachial artery after reactive hyperemia.Unit of Measure: mm
Absolute flow-mediated dilation (FMDabs)Measured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Absolute change in diameter, calculated as peak diameter minus basal diameter.Unit of Measure: mm
Standardized FMDMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Flow-mediated dilation adjusted for relevant covariates (e.g., shear stress, baseline diameter) according to standard protocols.Unit of Measure: %
Body weightMeasured at baseline, mid-intervention (approximately 3-4 weeks), and post-intervention (after 6-8 weeks).Body weight measured by bioelectrical impedance analysis (InBody device).Unit of Measure: kg
Study locations
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No public site location was included in this record. Check the original registry for updates.
