Clinical trial

The ISAR InflEx Trial (Inflammation and Exercise)

Recruiting now · Not applicable · 1 countries · Registry ID NCT07543666

Recruiting nowNot applicableInterventional

What this study is about

A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 45 Years

SexAll

Healthy volunteersNot accepted

ConditionInflammation, Obesity (Disorder)

Full registry criteria

Inclusion Criteria: * BMI 25.0 - 30.0 kg/m² * age 18 - 45 years * informed consent * no regular physical activity (≤1x/week of structured exercise) * willingness to strictly follow and adhere to the intervention protocol for the entire study Exclusion Criteria: * any acute or chronic illness * pregnancy and breastfeeding * active smoking * Regular use of medication

Treatments and study arms

moderate-intensity exercise

Procedure

Guideline recommended 150 min/week of moderate-intensity aerobic physical exercise (40-50% VO2peak) on 5 days per week (30 min per session)

vigorous-intensity exercise

Procedure

Guideline recommended 75 min/week of vigorous-intensity physical exercise (70-80% VO2peak) on 5 days per week (15 min per session)

short bouts of maximal exercise

Procedure

Maximal vigorous-intensity physical exercise for 1 minute twice per day (\>90% VO2peak) on 5 days per week (1 min per session, total of 2 min per day)

Primary outcomes

Changes in blood leukocyte levels pre- and post-interventionFrom enrollment to the end of the last intervention at 15 weeks

Study locations

1 locations were listed when this page was built. The first 40 are shown.

German Heart Centre🇩🇪 München, Bavaria, Germany

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Hendrik B Sager, MDContact

Email · Call 00498912184025