Clinical trial

JiGenerations Health Cohort Study：Parental Exposure and Intergenerational Health in China

Active, not recruiting · Not applicable · 1 countries · Registry ID NCT07514377

Active, not recruitingNot applicableObservational

What this study is about

The growing recognition of maternal health's impact on offspring necessitates large-scale prospective cohort studies spanning the maternal-child life cycle. This study establishes a family-centered birth cohort of 100,000 Chinese participants, tracking from preconception through offspring adolescence to investigate early-life health trajectories and intergenerational transmission of diseases, health status, and psychological-behavioral patterns. Data collection includes biospecimens (placenta, cord blood, breast milk, blood, urine, feces) and multi-omics analysis (genomic, proteomic, metabolomic, microbiomic), alongside clinical information from preconception, pregnancy, birth through childhood (0-14 years). The cohort covers 24 stratified sites across China, incorporating real-time environmental monitoring (air pollution, meteorological data) and sociogeographic factors. Targeting reproductive-age couples (18-45 years) and their offspring, the study addresses multigenerational health linkages, urban-rural disparities, and regional diversity from 2025 to 2039. By integrating genetic, environmental and lifestyle data, this research will identify critical intervention windows and mechanisms for chronic disease transmission across generations, supporting China's "Healthy China" initiative and developing targeted strategies for population health and aging.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age1 Day to 45 Years

SexAll

Healthy volunteersAccepted

ConditionEnvironmental Exposure, Fertility, Health Problems in Pregnancy, Adverse Pregnancy Outcomes, Birth Defects, Child Development, Metabolic Abnormality, Growth Retardation, Overweight and Obesity, Non-alcoholic Fatty Liver Disease

Full registry criteria

Inclusion Criteria: 1. Parental Generation: Eligible participants include couples of reproductive age who undergo free pre-pregnancy eugenic health examinations, or pregnant women registered for prenatal care at healthcare institutions during early pregnancy (≤14 weeks). The participants are aged 18-45 years old and have mobile phones and internet (computer) devices. All participants must provide informed consent and commit to long-term follow-up. The participants have no serious neuropsychiatric disorders, with sufficient understanding and expression to complete the survey. 2. Offspring Generation: Newborns whose parents participated in pre-pregnancy eugenic health checks and/or maternal prenatal examinations are enrolled in the cohort upon parental (guardian) consent. Designated hospitals will provide expedited medical services, free physical examinations, free child healthcare, and free psychological counseling to ensure comprehensive follow-up spanning infancy, preschool, school age, and early adolescence (0-14 years). Exclusion Criteria: 1. Intellectual disability or other serious mental disorders; 2. Suffering from serious underlying diseases and may have a significant impact on pregnancy outcome; 3. Those with poor compliance and difficulty in follow-up.

Treatments and study arms

N/A (Observational Study)

Other

This is an observational cohort study. No interventions are assigned. Groups are defined based on different condition or exposure.

Primary outcomes

Adverse pregnancy outcomesAt delivery

the rate of different adverse pregnancy outcomes

Study locations

1 locations were listed when this page was built. The first 40 are shown.

National Research Institute for Family Planning🇨🇳 Beijing, Beijing Municipality, China

Open map