Clinical trial

Postnatal Exercise to Activate Baby's Brown Fat

Recruiting now · Not applicable · 1 countries · Registry ID NCT07467694

Recruiting nowNot applicableInterventional

What this study is about

The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk. Certain changes in breast milk after exercise may have an impact on how infants use energy. Understanding this process may improve public health recommendations for exercise during and after pregnancy. This study can help investigators learn more about how maternal exercise patterns may affect body growth and obesity risk in infants who are breastfed. This research may help identify how different factors can influence healthy weight and early development in infants.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 45 Years

SexFemale

Healthy volunteersAccepted

ConditionChildhood Obesity Prevention, Childhood Obesity, Physical Activity, Lactation, Breastfeeding, Pregnancy, Exercise

Full registry criteria

Inclusion Criteria: * 18-45 y of age at the time of enrollment * Pre-gravid or first trimester BMI 18.5 -40 kg/m2 * Uncomplicated singleton pregnancy * Intention to exclusively breastfeed for \>3 months and, if parity \>1, that they successfully breastfed a previous pregnancy * Term pregnancy (gestational age 37 to \<42 weeks) * Infant with birth weight \>10th percentile of weight for gestational age Exclusion Criteria: * Any obstetric contra-indication to exercise at 1 month * Diagnosis of uncontrolled (HbA1c \>7%) type 1 or type 2 diabetes, or gestational diabetes managed with insulin * Intrauterine growth restriction * Pre-eclampsia or other pregnancy complications * Alcohol, cannabis or tobacco use * Known congenital metabolic, endocrine disease, or congenital illness affecting infant feeding/growth * Major fetal anomalies * Musculoskeletal issues that would make exercise difficult

Treatments and study arms

Active group

Behavioral

For participants randomized to the Active group, there will be weekly phone calls with study staff during which step counts and exercise bouts from the previous week will be reviewed, and exercise goals for the following week will be gradually increased.

Primary outcomes

Altered breast milk lipidome8 weeks

Milk composition measured through lipidomics

Altered breast milk metabolome8 weeks

Human milk composition measured via metabolomics

Study locations

2 locations were listed when this page was built. The first 40 are shown.

Joslin Diabetes Center🇺🇸 Boston, Massachusetts, United States

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Elvira Isganaitis, MDContact

Oklahoma University College of Medicine🇺🇸 Oklahoma City, Oklahoma, United States

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Katy DuncanContact

David Fields, PhDPrincipal Investigator