Clinical trial
A Two-armed Real-world Study of Ozempic (OW Semaglutide) to Evaluate Its Adherence and Persistence Compared With Other Anti-diabetic Drugs Among Adult T2DM Patients in China
Invitation only · Not applicable · 1 countries · Registry ID NCT07456774
Invitation onlyNot applicableObservational
What this study is about
The study is testing the incidence of MACE and incidence of renal events between Ozempic® users and users with other anti-diabetic medications in T2D patients. This is a retrospective study, and participants had received Ozempic or any other anti-diabetic medications.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionType 2 Diabetes
Full registry criteria
Inclusion Criteria: * Participants had at least one prescription for Ozempic® or other interested anti-diabetic medications during the index identification period. * Participants had at least one diagnosis of T2D, and had at least one of the three following T2D clinical evidence any time before or on the index date * Participants had at least 1 all-cause visit record any time after 6 months post-index date. * At least 18 years old at the index date. Exclusion Criteria: * Patients who have used any same anti-diabetic medications as the index treatment within 6 months before index date (e.g., patient prescribed with any Ozempic® during baseline will be excluded if the index drug is a Ozempic®) * Patients with any diagnosis record of type 1 diabetes or gestational diabetes during whole study period. * Patients who were pregnant during the whole study period. * Patients who participated in any clinical trials during the whole study period. * Patients who were diagnosed with medullary thyroid carcinoma or multiple endocrine neoplasia type II (MEN2) during the whole study period.
Treatments and study arms
The registry does not list a named intervention.
Primary outcomes
Time to 3P major adverse cardiovascular eventsFrom index date to the first composite 3P MACE (stroke, myocardial infarction, all-cause death) event or censoring event (up to 36 months)
Measured in days.
Time to 5P MACEFrom index date to the first composite 5P MACE (stroke, myocardial infarction, all-cause death, heart failure hospitalization, coronary revascularization) event or censoring event (up to 36 months)
Measured in days.
Time to strokeFrom index date to the first stroke event or censoring event (up to 36 months)
Measured in days.
Time to myocardial infarction (MI)From index date to the first MI event or censoring event (up to 36 months)
Measured in days.
Time to heart failure (HF)From index date to the first HF event or censoring event (up to 36 months)
Measured in days.
Time to composite renal eventFrom index date to first composite renal (kidney failure: dialysis/transplantation/eGFR <15, ≥50% eGFR reduction from baseline, or kidney-related/cardiovascular death) or censoring event (up to 36 months)
Measured in days.
Time to renal disease-related hospitalizationFrom index date to the first renal disease-related hospitalization or censoring event (up to 36 months)
Measured in days.
Incidence rate of 3P MACEFrom index date to the first composite 3P MACE (stroke, myocardial infarction, all-cause death) event or censoring event (up to 36 months)
Measured in Percentage, per 1000 patient year.
Study locations
1 locations were listed when this page was built. The first 40 are shown.
NIS- Tianjin Medical University Chu Hsien-I Memorial Hospital-Department of Endocrinology🇨🇳 Tianjin, Tianjin Municipality, China