Clinical trial

Effect of 8 Weeks of Resistance Training With Blood Flow Restriction on Muscle Strength, Clinical Parameters, Biochemical Biomarkers, and Perceived Exertion in Adults With Obesity

Invitation only · Not applicable · 1 countries · Registry ID NCT07444736

Invitation onlyNot applicableInterventional

What this study is about

To analyze the effect of 8 weeks of resistance training with blood flow restriction on muscle strength, clinical parameters, biochemical biomarkers, and perceived exertion in adults with obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 30 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity & Overweight

Full registry criteria

Inclusion Criteria: * Adults aged 18 to 40 * Both genders * BMI ≥ 30 kg/m\^2 and \< 40 kg/m\^2 * Signed informed consent form Exclusion Criteria: * Participants who smoke * Personal and family history of vascular disease or deep vein thrombosis * Clinical diagnosis of hypothyroidism * Clinical diagnosis of type 1 diabetes mellitus * Clinical diagnosis of type 2 diabetes mellitus * Clinical diagnosis of grade 3 obesity * Clinical diagnosis of hypertension * Clinical diagnosis of acute myocardial infarction or angina pectoris * Use of nitrates and calcium channel blockers within 4 days prior to the start of the study * Use of anticoagulants * Use of beta-blockers or hypoglycemic agents within 7 days prior to the intervention * Pregnant women * Breastfeeding women * Men consuming more than 40 g of alcohol per day or women consuming more than 20 g per day * Postural and biomechanical disorders (knee, foot, and spine)

Treatments and study arms

Intervention

Other

The BFR group will perform machine-based quadriceps extension exercises and dumbbell biceps curls involving both lower limbs and both upper limbs. Each exercise will consist of 4 sets of 12 repetitions. Quadriceps extensions will be performed at an intensity of 40% of one-repetition maximum (1RM), and biceps curls at 20% of 1RM. The execution cadence will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase. Inter-set rest intervals will be 1 minute. For vascular occlusion, a Carbafix cuff (8 cm width × 68 cm length for the upper limb; 10.5 cm width × 106.0 cm length for the lower limb) will be applied directly to the skin at the most proximal portion of the arm or thigh. The cuff will be inflated to 20 mmHg above resting brachial systolic blood pressure. To ensure partial vascular occlusion, pulse and oxygen saturation will be assessed using a pulse oximeter at the end of each set. Cuff pressure will be released during the inter-set rest periods.

Intervention

Other

The control group will perform quadriceps extensions and biceps curls, completing 4 sets of 10 repetitions at an intensity of 70% of one-repetition maximum (1RM). The execution tempo will be standardized to 1 second for the concentric phase and 2 seconds for the eccentric phase, with 2-minute inter-set rest intervals. The protocol will adhere to the resistance training guidelines established by the American College of Sports Medicine (ACSM)

Primary outcomes

Muscle strengthBaseline and after 8 weeks

Muscle strength (kg): Change from baseline to 8 weeks of intervention. Muscle strength will be assessed using dynamometry

Dynamic muscle strengthBaseline and after 8 weeks

Dynamic muscle strength (kg): Change from baseline to 8 weeks of intervention.

Arm circumferenceBaseline and after 8 weeks

Arm circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol

Thigh circumferenceBaseline and after 8 weeks

Thigh circumference (cm): Change from baseline to 8 weeks of intervention. Measurements will be obtained using a non-elastic measuring tape in accordance with the International Society for the Advancement of Kinanthropometry (ISAK) protocol

Maximum oxygen uptake (VO₂max)Baseline and after 8 weeks

VO₂max (ml/min/kg): Change from Baseline at 8 weeks, measured using a submaximal exercise test based on the Åstrand-Ryhming protocol

Systolic blood pressure (SBP)Baseline and after 8 weeks

SBP (mmHg): Changes from baseline to 8 weeks of intervention

Diastolic blood pressure (DBP)Baseline and after 8 weeks

DBP (mmHg): Changes from baseline to 8 weeks of intervention

Heart rateBaseline and after 8 weeks

Heart rate (bpm): Change from baseline to 8 weeks of intervention.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Centro Universitario de Tlajomulco🇲🇽 Tlajomulco de Zúñiga, Jalisco, Mexico

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