Clinical trial

Effect of Electroacupuncture on Central Obesity and Fatty Liver in Postmenopausal Women

Opening soon · Not applicable · 1 countries · Registry ID NCT07437001

Opening soonNot applicableInterventional

What this study is about

The aim of this study is to determine the effect of electroacupuncture on central obesity and fatty liver in postmenopausal women.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age50 Years to 60 Years
SexFemale
Healthy volunteersNot accepted
ConditionPostmenopausal Women

Full registry criteria

Inclusion Criteria: 1. Their ages will be ranged between 50 and 60 years old. 2. Their body mass index will be ranged from 30-40 kg/m2. 3. SGOT more 40 U/L. 4. SGPT more 40 U/L. 5. Waist/Hip Ratio more 1 cm. 6. Triglyceride more 150 mg/dl. 7. Cholesterol more 200 mg/dl. 8. LDL more 100 mg/dl. 9. HDL less 40 mg/dl. Exclusion Criteria: 1. Cancer. 2. Concomitant cardiovascular disorders. 3. Respiratory, renal and liver dysfunction.

Treatments and study arms

Medical treatment

Drug

All women in both groups will adhere to the same medication (orlistat) as prescribed by the gynecologist for 12 weeks.

Hypocaloric diet

Other

All women in both groups will be instructed to follow the same hypocaloric diet, as prescribed by a certified nutrition specialist, with a daily caloric intake of 1,200 kcal for a duration of 12 weeks.

Electroacupuncture

Other

Women in the experimental group only will undergo electroacupuncture three times per week for 12 weeks. Treatment will be delivered in the supine position using sterile needles inserted at eight standardized acupoints associated with central obesity and weight regulation, with insertion depths of 10-25 mm. Low-frequency electrical stimulation (2 Hz, 0.5 ms) will be applied to the abdominal region for 30 minutes per session.

Primary outcomes

Body Mass Index (BMI)12 weeks

BMI will be calculated as weight in kilograms divided by height in meters squared (kg/m²). Height will be measured using a stadiometer, and BMI will be assessed at baseline and post-intervention. BMI serves as a primary outcome as it provides a standardized indicator of overall obesity and treatment-related changes in adiposity.

Waist Circumference12 weeks

Waist circumference will be measured at the narrowest point between the xiphoid process and the iliac crest at the end of gentle expiration, with participants standing. This measure directly reflects central obesity and is therefore considered a primary outcome.

Hip Circumference12 weeks

Hip circumference will be assessed at the level of maximum circumference over the femoral trochanters.

Waist-to-Hip Ratio (WHR)12 weeks

WHR will be calculated by dividing waist circumference by hip circumference. This index reflects fat distribution and cardiometabolic risk, making it a primary outcome for central obesity assessment.

Serum Glutamic-Oxaloacetic Transaminase (SGOT / AST)12 weeks

In the context of fatty liver disease, elevated SGOT levels reflect the degree of hepatic inflammation and cellular stress associated with lipid accumulation within hepatocytes. This biomarker will be measured from venous blood samples collected from the antecubital fossa of each participant at baseline and following the completion of the 12-week intervention. Samples will undergo centrifugation within eight hours of collection, with serum preserved at -20°C pending laboratory analysis.

Serum Glutamic-Pyruvic Transaminase (SGPT / ALT)12 weeks

Elevated SGPT activity in the serum is considered a hallmark biochemical indicator of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation most commonly associated with central obesity and insulin resistance in postmenopausal women. Blood samples will be drawn from the antecubital vein of each participant before and after the 12-week treatment period, centrifuged within eight hours of collection, and the resulting serum stored at -20°C until analysis.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Aga Central Hospital🇪🇬 Aga, Egypt
Mohamed Abdel Hamid El Maghwary ElGaedy, M.ScContact