Clinical trial

Snacking Effects on the Brain Response to Foods and Satiety During Dieting

Recruiting now · Not applicable · 1 countries · Registry ID NCT07428187

Recruiting nowNot applicableInterventional

What this study is about

This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age25 Years to 45 Years
SexAll
Healthy volunteersNot accepted
ConditionOverweight/Obesity

Full registry criteria

Inclusion Criteria: * 25-45 years old * BMI at least 27 kg/m2 * Comfortable completing a weight-loss intervention\\ * Willing to consume a daily snack of either walnuts or pretzels Exclusion Criteria: * Nut or wheat allergy * History of bariatric surgery * Current eating disorder * Current illicit substance use * Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum * Uncontrolled hypertension (\>160/100 mmHg) * Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results * Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment * Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists) * Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns) * Neurological illnesses or injury that would be anticipated to affect MRI data * Weight change greater than 10% within 3 months prior to study participation * Currently participating in another weight-loss study * Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan) * MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs

Treatments and study arms

Snack Type 1: Walnuts

Other

Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team.

Snack Type 2: Pretzels

Other

Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team.

Primary outcomes

Percent change in Blood Oxygen Level Dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imagingBaseline, 12 weeks

Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, amygdala, and prefrontal cortex.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

University of Colorado Anschutz Medical Campus🇺🇸 Aurora, Colorado, United States
Kristina Legget, PhDContact
Allison Hild, BSContact
Kristina T Legget, PhDPrincipal Investigator