Clinical trial

Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals

Opening soon · Not applicable · 1 countries · Registry ID NCT07423884

Opening soonNot applicableInterventional

What this study is about

This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity. The traditional Minangkabau foods used in this study consist primarily of coconut milk-based dishes, which contain coconut oil as a natural source of MCTs. The metabolic biomarkers assessed include body mass index (BMI), waist circumference, systolic and diastolic blood pressure, body fat percentage, fasting blood glucose levels, lipid profile, leptin concentrations, and DNA methylation of the leptin gene promoter. Based on these metabolic biomarker measurements, participants will be classified into metabolic obesity phenotypes, namely metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The researchers hypothesize that the provision of a low-calorie, MCT-rich diet based on traditional Minangkabau foods will have a significant effect on metabolic biomarkers and metabolic status in individuals with obesity.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionMetabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin, Obesity

Full registry criteria

Inclusion Criteria: * Administrative staff of the Faculty of Medicine and the Faculty of Public Health, Andalas University, Padang, with obesity defined as a body mass index (BMI) ≥ 25 kg/m². * Willing to participate in the study by providing written informed consent. * Participants with obesity classified as Metabolically Unhealthy Obese (MUHO) Exclusion Criteria: * Did not come and could not be found at the time of research data collection * Unable to follow the dietary arrangements as set * Taking anti-diabetic or anti-lipid drugs * Use of contraceptives or hormonal drugs * In the treatment of radiotherapy or chemotherapyi * Participants with obesity classified as Metabolically Healthy Obese (MHO)

Treatments and study arms

Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods

Other

Participants in the intervention group received a nutritionally balanced low-calorie diet rich in medium-chain triglycerides (MCTs) derived from traditional Minangkabau foods. The dietary intervention was designed to provide an energy deficit of 500-600 kcal compared with participants' habitual daily intake. Assessments were conducted before and after the intervention period.

Primary outcomes

Change from baseline in body mass index (BMI).After 12 weeks

BMI is calculated as body weight in kilograms divided by the square of height in meters (kg/m²).

Change from baseline in waist circumference.After 12 weeks

Waist circumference is measured around the abdomen at the level of the umbilicus.

Change from baseline in body fat percentageAfter 12 weeks

Body fat percentage is assessed using bioelectrical impedance analysis (BIA).

Change from baseline in systolic and diastolic blood pressureAfter 12 weeks

Blood pressure is measured using a digital tensimeter.

Change from baseline in fasting blood glucose levels.After 12 weeks

Fasting blood glucose levels are measured using a clinical chemistry analyzer.

Change from baseline in lipid profile.After 12 weeks

The lipid profile includes total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol. Measurements are performed using a clinical chemistry analyzer (photometer).

Change from baseline in serum leptin.After 12 weeks

Serum leptin concentrations are measured using appropriate laboratory methods (ELISA).

Change from baseline in DNA methylation of the leptin gene promoter.After 12 weeks

DNA methylation status of the leptin gene promoter is assessed using MSP (Methylation-Specific PCR).

Study locations

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Prof. Nur Indrawaty Lipoeto🌐 Padang, West Sumatera, Indonesia

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Lipoeto, ProfessorContact

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