Clinical trial

Supersaturated Hydrogen-Rich Water for Outpatients With Persistent Excess Weight

Opening soon · Not applicable · 1 countries · Registry ID NCT07410065

Opening soonNot applicableInterventional

What this study is about

The Supersaturated Hydrogen-Rich Water for Outpatients with Persistent Excess Weight (HOPE) study is a Phase III, multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of daily consumption of supersaturated hydrogen-rich water in adults with persistent excess body weight. The trial investigates whether sustained exposure to molecular hydrogen can favorably influence body composition and key metabolic outcomes compared with a placebo water lacking dissolved hydrogen. By enrolling outpatients across multiple centers and applying rigorous blinding and randomization procedures, HOPE aims to generate high-quality clinical evidence on the potential role of hydrogen-rich water as a non-pharmacological, adjunctive strategy for weight management and metabolic health.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to Not listed

SexAll

Healthy volunteersAccepted

ConditionOverweight

Full registry criteria

Inclusion Criteria: * Age \> 18 years * Body mass index \> 25.0 kg/m2 (persisted for at least six months before screening) * Stable on their therapy (if any) for ≥ 3 months * Free of acute disorders and severe chronic diseases * Informed consent signed * Normal fasting breath hydrogen levels \< 15 ppm Exclusion Criteria: * History of dietary supplement use 4 weeks before the study commences * Abnormal values for lab clinical chemistry not related with stiyd outcomes (\> 2 SD) * No consent to randomization * Unwillingness to return for follow-up analysis * Participation in other clinical trials * Participants starting or changing major treatments during the study period

Treatments and study arms

Hydrogen-rich water

Dietary Supplement

Hydrogen-rich water (1.0 L per day)

Control

Dietary Supplement

Hydrogen-free water (1.0 L per day)

Primary outcomes

Apolipoprotein BChange from baseline apolipoprotein B at 6 months

Serum level of apolipoprotein B

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Center for Health Sciences🌐 Belgrade, Serbia

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