Clinical trial

Predicting Weight Loss After Pharmacological or Surgical Treatment in Patients With Obesity

Recruiting now · Not applicable · 1 countries · Registry ID NCT07402031

Recruiting nowNot applicableObservational

What this study is about

As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence. Recent evidence on anti-obesity medication indicate similar inter-individual variability in clinical response. Among multiples factors, co-occurrence of eating disorders such as binge eating disorder has been implicated in insufficient clinical response. Improving our ability to predict how patients will respond to obesity treatment is necessary in order to tailor the care pathways we offer. The mechanisms involved in disturbances of eating behaviour before and after surgery remain largely unknown. This study aims to identify the predictive factors of weight loss after pharmacological or surgical treatment, as well as the cognitive and biological mechanisms that mediate this effect.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 65 Years

SexAll

Healthy volunteersNot accepted

ConditionObesity & Overweight

Full registry criteria

Inclusion criteria: * Age between 18 and 65 years * Obesity, with bariatric surgery indicated after a multidisciplinary evaluation in case of surgical treatment. * Good physical and mental health, enabling informed consent. * French speaker Exclusion criteria: * Legal protection * Pregnancy or breastfeeding * History of bariatric surgery (except gastric banding, provided it was removed more than five years ago). * Acute or progressive chronic disease * Alcohol consumption of more than 20 g/day * Inflammatory bowel disease; * Digestive autonomic diabetic neuropathy. * Consumption of dietary supplements (stanols, probiotics, prebiotics or omega-3). * Following a vegan or gluten-free diet or being lactose intolerant. * Fibre consumption \>30 g/day * Recent change in antidiabetic medication within the past 3 months.

Treatments and study arms

Pharmacological or surgical treament of obesity

Procedure

Longitudinal follow-up of participants who initiate an anti-obesity medication or whose application for bariatric surgery was accepted. It will combine anthropometric, clinical, neuropsychological and biological measurements taken at various timepoints. Participants will be asked to complete a set of online questionnaires and data will be recorded anonymously. Biological samples will be collected at various time points.

Primary outcomes

Correlation between weight loss after treatment and clinical, neuropsychological and biological parameters.Throughout the entire study, aproximately during 5 years

The percentage of excessive weight loss after treatment will be correlated with * Clinical parameters (Binge Eating Scale and modified Yale Food Addiction Scale 2.0) * Neuropsychological parameter (Barratt Impulsivness Scale and Trail Making Test) * Biological parameters

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Cliniques Universitaires Saint-Luc🇧🇪 Brussels, Brussels Capital, Belgium

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Dr Yannick Deswysen, DoctorContact

Email · Call +32 (0) 2 764 22 13

Yannick Deswysen, DoctorPrincipal Investigator

Audrey Loumaye, ProfessorSub Investigator