Clinical trial
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
Recruiting now · Phase 3 · 4 countries · Registry ID NCT07392190
Recruiting nowPhase 3Interventional
What this study is about
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age18 Years to Not listed
SexAll
Healthy volunteersNot accepted
ConditionOverweight, Obesity
Full registry criteria
Inclusion Criteria: * Are on stable incretin therapy at screening * With persistent obesity or overweight defined as: * ≥30 kg/m2 OR * ≥27 kg/m2 with at least one existing obesity related complication at screening: * hypertension * dyslipidemia * obstructive sleep apnea * cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or * type 2 diabetes * Have a stable body weight (\<5% body weight change) at screening Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following antihyperglycemic medications within 90 days before screening: * dipeptidyl peptidase-4 (DPP-4) inhibitors * amylin analogs * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
Treatments and study arms
Eloralintide
Drug
Administered SC
Placebo
Drug
Administered SC
Primary outcomes
Percent Change from Baseline in Body WeightBaseline, Week 64
Study locations
187 locations were listed when this page was built. The first 40 are shown.
Royal Brisbane and Women's Hospital🇦🇺 Brisbane, Australia
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Donald McLeodPrincipal Investigator
Austin Health - Repatriation Hospital🇦🇺 Heidelberg West, Australia
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Elif EkinciPrincipal Investigator
AIM Research🇦🇺 Merewether, Australia
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Claire MorbeyPrincipal Investigator
Southern Adelaide Diabetes & Endocrine Services🇦🇺 Oaklands Park, Australia
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Jui HoPrincipal Investigator
Imelda General Hospital🇧🇪 Bonheiden, Belgium
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Chris VercammenPrincipal Investigator
Université Libre de Bruxelles - Hôpital Erasme🇧🇪 Brussels, Belgium
Laurent CrenierPrincipal Investigator
Ziekenhuis Oost-Limburg, Campus St.-Jan🇧🇪 Genk, Belgium
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David VerhaertPrincipal Investigator
Jan Yperman Ziekenhuis🇧🇪 Ieper, Belgium
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An NolletPrincipal Investigator
AZ Groeninge Campus Kennedylaan🇧🇪 Kortrijk, Belgium
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Gerd VanhaverbekePrincipal Investigator
UZ Leuven🇧🇪 Leuven, Belgium
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Roman VangoitsenhovenPrincipal Investigator
AZ Sint-Maarten🇧🇪 Mechelen, Belgium
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Michel VandenbrouckePrincipal Investigator
Meclinas🇧🇪 Mechelen, Belgium
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Julie CasaerPrincipal Investigator
Az Damiaan vzw🇧🇪 Ostend, Belgium
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Marianne KerrebrouckPrincipal Investigator
Centro de Diabetes Curitiba🇧🇷 Curitiba, Brazil
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LUCIANA PECHMANNPrincipal Investigator
Quanta Diagnóstico e Terapia🇧🇷 Curitiba, Brazil
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Rosangela ReaPrincipal Investigator
Private Practice - Dr.Miguel N. Hissa🇧🇷 Fortaleza, Brazil
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Miguel HissaPrincipal Investigator
CPCLIN🇧🇷 São Paulo, Brazil
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Denise FrancoPrincipal Investigator
Hospital 9 De Julho🇧🇷 São Paulo, Brazil
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Layana Sandes FragaPrincipal Investigator
CEDOES🇧🇷 Vitória, Brazil
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Queulla SantosPrincipal Investigator
Integral Pesquisa e Ensino🇧🇷 Votuporanga, Brazil
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GRACIELLY PANTANOPrincipal Investigator
The First Hospital of Jilin University🇨🇳 Changchun, China
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Guixia WangPrincipal Investigator
The Second Xiangya Hospital of Central South University🇨🇳 Changsha, China
Xia LiPrincipal Investigator
West China Hospital Sichuan University🇨🇳 Chengdu, China
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zhenmei anPrincipal Investigator
2nd Affiliated Hospital Chongqing Medical Universi🇨🇳 Chongqing, China
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Dongfang LiuPrincipal Investigator
The Affiliated Hospital of Guizhou Medical University🇨🇳 Guiyang, China
Miao ZhangPrincipal Investigator
The Second People's Hospital of Hefei🇨🇳 Hefei, China
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Jun YePrincipal Investigator
The First Affiliated Hospital of Henan University of Science &Technology🇨🇳 Luoyang Shi, China
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Hongwei JiangPrincipal Investigator
Jiangxi Provincial People's Hospital🇨🇳 Nanchang, China
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Zongyou ChengPrincipal Investigator