Clinical trial

Assessing Obesity Related Risk Factors in Adult Population: A Genetic and Behavioral Study

Invitation only · Not applicable · 1 countries · Registry ID NCT07341841

Invitation onlyNot applicableInterventional

What this study is about

This study aims to explore the association between Melanocortin-4 Receptor (MC4R) polymorphisms, eating habits, and social determinants of health in a heterogeneous adult population in Georgia, USA.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age18 Years to 70 Years

SexAll

Healthy volunteersAccepted

ConditionObesity Prevention

Full registry criteria

Inclusion Criteria: Adults 18-70 years old are included in the study. Target populations are 4 groups: * Group 1 - overweight (not obese), if BMI is 25.0-29.9 Kg/m2; * Group 2 - Class 1 (lower-risk) obesity, if BMI is 30.0-34.9 Kg/m2; * Group 3 - Class 2 (moderate-risk) obesity, if BMI is 35-39.9 Kg/m2 and * Group 4 - Class 3 (high-risk) obesity, if BMI is equal or greater than 40 Kg/m2. Males and females will participate in the study. Exclusion Criteria: Children younger than 18 years old and adults over 70 are excluded from the study. Non-English speakers and individuals with impaired decision-making capacity to consent are excluded from the study.

Treatments and study arms

Diet and exercise

Behavioral

Diet intervention: Participants will be randomly divided into a control group (n=50) and a training group (n=50) using the simplest method of assigning participants to different treatment groups: a coin toss. They will be surveyed using the modified DHII questionnaire to assess their caloric intake. The baseline calorie intake will be evaluated during the first visit. Participants will be instructed to reduce their portion sizes by half of what they typically consume. The commitment of participants will be for 8 weeks. Exercise intervention: In the first visit, subjects will be familiarized with exercise on a bicycle ergometer to eliminate the novel effects of a new experience. The subjects in the training group will then come to our laboratory to participate in an 8-week exercise program; the control group will not undergo training during this experimental period. The training group will train on a bicycle ergometer for 30 minutes, 3 days a week, for 8 weeks.

Lifestyle Intervention

Behavioral

8-week personalized diet using a personalized low-calorie diet based on the caloric intake baseline using modified Diet History Questionnaire II (DHQ II)

Exercise

Behavioral

8-week personalized physical activity- subjects will be doing 30-minute exercise three times a week using a bicycle ergometer

Primary outcomes

Diet and exercise8 weeks

Calorie intake, BMI, % fat, % lean mass.

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Augusta University🇺🇸 Augusta, Georgia, United States

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