Clinical trial

Pistachio Snacking and Metabolic Flexibility

Recruiting now · Not applicable · 1 countries · Registry ID NCT07340125

Recruiting nowNot applicableInterventional

What this study is about

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.

Basic eligibility

Age25 Years to 45 Years

SexAll

Healthy volunteersAccepted

ConditionOverweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²), Poor Sleep Quality, Healthy Participants, Physically Inactive

Full registry criteria

Inclusion Criteria: * Males and Females * Age: 25-45 years * Overweight or obese (BMI=25.0-34.9 kg/m²) * Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5) * Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test) * Not meeting weekly physical activity recommendations (\<150 min moderate-intensity exercise, \<75 minutes of vigorous-intensity exercise, and \<2 days of strength training) * Not following a diet that is restrictive or eliminates certain food group/types Exclusion Criteria: * Allergies to nuts, especially tree nuts * Has a pacemaker * Following a diet that is restrictive or eliminates certain food group/types * Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer/cancer treatment (within the past year) * History of gastrointestinal surgery, hysterectomy * For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal

Treatments and study arms

Pistachio

Other

Roasted, lightly salted, pistachio kernels (no shell)

Primary outcomes

resting metabolismDay 0 and Day 5

resting metabolic rate (RMR) and substrate utilization (RER) via indirect calorimetry

exercise metabolic flexibilityDay 0 and Day 5

substrate metabolism (RER; indirect calorimetry) throughout a submaximal, graded exercise test

post-exercise metabolismDay 0 and Day 5

Energy expenditure and substrate metabolism (RER) measured at 0, 30, 60, 90min post-exercise via indirect calorimetry

Study locations

1 locations were listed when this page was built. The first 40 are shown.

Public Health Research Center: Clinical Exercise Research Center🇺🇸 Columbia, South Carolina, United States

Open map