Recruiting nowNot applicableInterventional
What this study is about
This project aims to study the effect of exercise in the obesity/overweight on the changes of physical fitness and blood components. This will provide novel knowledge for medical staffs, researchers, or companies developing alternative strategies for treating obesity/overweight, including drug development and health promotion project to delay or prevent the onset of the disease.
A promising-looking record is not the same as confirmed eligibility. The study team must review the full criteria and current recruitment status.
Basic eligibility
Age25 Years to 45 Years
SexAll
Healthy volunteersNot accepted
ConditionObesity & Overweight
Full registry criteria
Inclusion Criteria: 1. Male or female individuals aged between 25-45 years 2. Thai nationality 3. Ability to walk or perform daily activities independently, without the use of an assistive device 4. Body mass index (BMI) between 25-35 kg/m² 5. Low physical activity levels or sedentary lifestyle based on the World Health Organization 2020 * The levels of moderate-intensity physical activity \< 150-300 minutes per week or the levels of vigorous-intensity physical activity \< 75-150 minutes per week * Moderate-intensity physical activity: fast walking and bicycling. Vigorous-intensity physical activity: running, aerobic dance, and swimming All participants are required to meet all inclusion criteria to be eligible for the research project. Exclusion Criteria: 1. Smoking, substance abuse, or alcohol addiction 2. History of respiratory diseases, such as asthma, emphysema, or chronic obstructive pulmonary disease 3. History of cardiovascular diseases, such as coronary heart disease, aortic disease, arrhythmia, or deep vein thrombosis 4. History of high blood pressure (hypertension) 5. History of vestibular system diseases, such as Meniere's disease or otitis media 6. History of neurological disease, such as severe Parkinson's disease or stroke 7. History of previous lower limb surgery, such as hip, knee, or ankle replacement 8. History of musculoskeletal diseases, such as severe osteoarthritis 9. History of severe brain disease, such as dementia 10. Severe visual or hearing impairment 11. Have a cognitive and comprehensive impairment and unable to complete the intervention 12. Have high physical activity or regularly exercise
Primary outcomes
Blood component assessmentPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program within 1 hour)Participant's blood components, e.g. extracellular vesicles, will be investigated by cell assays and proteomic analysis
Foot pressure distribution8 times: Day 1 (Before and after HIIT program), Day 4-7 (after HIIT program only), Day 18 (Before and after HIIT program)Foot pressure distribution will be measured using a treadmill (Zebris FDM-T Treadmill System, zebris Medical GmbH, Germany)
Facial and abdominal fat thickness measurementPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)Facial and abdominal fat thickness and characteristics will be pictured and analyzed using ultrasound imaging
VO2maxPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)VO2max parameter (ml/kg/min) will be examined using Cardio Pulmonary Exercise Test
Body compositionPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)Body composition (%) will be measured by bioelectrical impedance analysis.
Heart ratePre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)Heart rate (beat/min) will be measured by pulse oximeters
Grip strengthPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)Grip strength (kg) will be measured by hand grip dynamometer
Leg strengthPre-training (Day 1 before HIIT program) and post-training (Day 18 after HIIT program)Leg strength (kg) will be measured by back-leg-chest dynamometer
